6ZRE
Deciphering the role of the channel constrictions in the opening mechanism of MexAB-OprM efflux pump from Pseudomonas aeruginosa
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Outer membrane protein OprM | polymer | 474 | 51547.4 | 2 | UniProt (Q51487) Pfam (PF02321) | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | |
| 2 | C (A) | PALMITIC ACID | non-polymer | 256.4 | 1 | Chemie (PLM) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | E, F, G, H, I... (A) | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 11 | Chemie (BOG) |
Sequence modifications
A, B: 1 - 468 (UniProt: Q51487)
| PDB | External Database | Details |
|---|---|---|
| Leu 403 | Arg 420 | engineered mutation |
| Phe 404 | Tyr 421 | engineered mutation |
| Ala 416 | Asp 433 | engineered mutation |
| Ala 419 | Arg 436 | engineered mutation |
| His 469 | - | expression tag |
| His 470 | - | expression tag |
| His 471 | - | expression tag |
| His 472 | - | expression tag |
| His 473 | - | expression tag |
| His 474 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 103094.9 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 3568.5 | |
| All* | Total formula weight | 106663.4 |
