6ZR5

Crystal structure of JNK1 in complex with ATF2(19-58)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Mitogen-activated protein kinase 8	polymer	366	42032.6	2	UniProt (P45983) Pfam (PF00069) In PDB	Homo sapiens (Human)	MAPK 8,JNK-46,Stress-activated protein kinase 1c,SAPK1c,Stress-activated protein kinase JNK1,c-Jun N-terminal kinase 1
2	C, D	Cyclic AMP-dependent transcription factor ATF-2	polymer	40	4585.3	2	UniProt (P15336) In PDB	Homo sapiens (Human)	cAMP-dependent transcription factor ATF-2,Activating transcription factor 2,Cyclic AMP-responsive element-binding protein 2,cAMP-responsive element-binding protein 2,HB16,Histone acetyltransferase ATF2,cAMP response element-binding protein CRE-BP1
3	A, B	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	A, B	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
5	C, D	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6		water	water		18.0	125	Chemie (HOH)

Sequence modifications

A, B: 1 - 364 (UniProt: P45983)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag

C, D: 20 - 58 (UniProt: P15336)

PDB	External Database	Details
Tyr 19	-	expression tag
Arg 34	Gln 34	engineered mutation
Arg 47	His 47	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	93235.6
Non-Polymers*	Number of molecules	8
	Total formula weight	1240.4
All*	Total formula weight	94476.1

*Water molecules are not included.