6ZR5

Crystal structure of JNK1 in complex with ATF2(19-58)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004707	molecular_function	MAP kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004707	molecular_function	MAP kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG A 401

Chain	Residue
A	ASN156
A	ANP402
A	HOH508

---

site_id	AC2
Number of Residues	19
Details	binding site for residue ANP A 402

Chain	Residue
A	LYS55
A	MET108
A	GLU109
A	MET111
A	ASN114
A	SER155
A	ASN156
A	LEU168
A	MG401
A	MG403
A	HOH508
A	HOH522
A	HOH529
A	ILE32
A	GLY33
A	GLY35
A	ALA36
A	GLN37
A	ALA53

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MG A 403

Chain	Residue
A	GLU73
A	ANP402
A	HOH501
A	HOH503

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN C 101

Chain	Residue
C	CYS27
C	CYS32
C	HIS45
C	HIS49

---

site_id	AC5
Number of Residues	17
Details	binding site for residue ANP B 400

Chain	Residue
B	ILE32
B	GLY35
B	ALA36
B	GLN37
B	VAL40
B	ALA53
B	LYS55
B	GLU109
B	MET111
B	ASN114
B	SER155
B	ASN156
B	MG401
B	MG402
B	HOH512
B	HOH531
B	HOH536

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MG B 401

Chain	Residue
B	ASN156
B	ANP400
B	HOH536
B	HOH539

---

site_id	AC7
Number of Residues	4
Details	binding site for residue MG B 402

Chain	Residue
B	LYS55
B	GLU73
B	ANP400
B	HOH531

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN D 101

Chain	Residue
D	CYS27
D	CYS32
D	HIS45
D	HIS49

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CtapgCgrrFtnedhlavHkrk..H

Chain	Residue	Details
C	CYS27-HIS49

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV

Chain	Residue	Details
A	ILE147-VAL159

---

site_id	PS01351
Number of Residues	103
Details	MAPK MAP kinase signature. FqnqthakrayRElvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqmeldhermsyllyqmlcgikhlhsagiih..........RDlKpsnivvksdC

Chain	Residue	Details
A	PHE61-CYS163

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P49185","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	295
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Motif: {"description":"TXY"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by MAP2K7","evidences":[{"source":"PubMed","id":"11062067","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by MAP2K4","evidences":[{"source":"PubMed","id":"11062067","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	48
Details	Zinc finger: {"description":"C2H2-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKC/PRKCH","evidences":[{"source":"PubMed","id":"22304920","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---