6ZOF
Fusidic acid binding to the TM7/TM8 groove of AcrB-F380A T protomer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Multidrug efflux pump subunit AcrB | polymer | 1057 | 114660.2 | 3 | UniProt (P31224) Pfam (PF00873) | Escherichia coli K-12 | AcrAB-TolC multidrug efflux pump subunit AcrB,Acridine resistance protein B |
| 2 | D, E (D, E) | DARPIN | polymer | 169 | 18317.6 | 2 | synthetic construct | ||
| 3 | F, G, N, O, Q (A, B, C) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 5 | Chemie (LMT) | |||
| 4 | H, R (A, C) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | I (B) | DECANE | non-polymer | 142.3 | 1 | Chemie (D10) | |||
| 6 | J (B) | DECYLAMINE-N,N-DIMETHYL-N-OXIDE | non-polymer | 201.3 | 1 | Chemie (DDQ) | |||
| 7 | K (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | L (B) | FUSIDIC ACID | non-polymer | 516.7 | 1 | Chemie (FUA) | |||
| 9 | M (B) | HEXADECANE | non-polymer | 226.4 | 1 | Chemie (R16) | |||
| 10 | P (C) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 1 | Chemie (PTY) | |||
| 11 | S, T, U (A, B, C) | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 1049 (UniProt: P31224)
| PDB | External Database | Details |
|---|---|---|
| Ala 380 | Phe 380 | engineered mutation |
| Leu 1050 | - | expression tag |
| Glu 1051 | - | expression tag |
| His 1052 | - | expression tag |
| His 1053 | - | expression tag |
| His 1054 | - | expression tag |
| His 1055 | - | expression tag |
| His 1056 | - | expression tag |
| His 1057 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 380615.7 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 4658.1 | |
| All* | Total formula weight | 385273.8 |
