6ZOF
Fusidic acid binding to the TM7/TM8 groove of AcrB-F380A T protomer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0015567 | molecular_function | alkane transmembrane transporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015895 | biological_process | alkane transport |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0042930 | biological_process | enterobactin transport |
| A | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098567 | cellular_component | periplasmic side of plasma membrane |
| A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| A | 1990281 | cellular_component | efflux pump complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0015567 | molecular_function | alkane transmembrane transporter activity |
| B | 0015721 | biological_process | bile acid and bile salt transport |
| B | 0015895 | biological_process | alkane transport |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0042930 | biological_process | enterobactin transport |
| B | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098567 | cellular_component | periplasmic side of plasma membrane |
| B | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| B | 1990281 | cellular_component | efflux pump complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009410 | biological_process | response to xenobiotic stimulus |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0015567 | molecular_function | alkane transmembrane transporter activity |
| C | 0015721 | biological_process | bile acid and bile salt transport |
| C | 0015895 | biological_process | alkane transport |
| C | 0015908 | biological_process | fatty acid transport |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042908 | biological_process | xenobiotic transport |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0042930 | biological_process | enterobactin transport |
| C | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| C | 0046677 | biological_process | response to antibiotic |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0098567 | cellular_component | periplasmic side of plasma membrane |
| C | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| C | 1990281 | cellular_component | efflux pump complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue LMT A 1101 |
| Chain | Residue |
| A | GLY440 |
| A | GLY444 |
| A | CYS887 |
| A | ALA890 |
| A | LEU891 |
| C | ARG8 |
| C | PHE11 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue LMT A 1102 |
| Chain | Residue |
| A | TYR541 |
| A | SER530 |
| A | ARG536 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1103 |
| Chain | Residue |
| A | LYS55 |
| A | GLY691 |
| A | HIS692 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue D10 B 1101 |
| Chain | Residue |
| B | LYS29 |
| B | ALA384 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue DDQ B 1102 |
| Chain | Residue |
| A | PHE11 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 1103 |
| Chain | Residue |
| B | ARG239 |
| B | ASP761 |
| C | PRO119 |
| C | GLN120 |
| C | GLU121 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue FUA B 1104 |
| Chain | Residue |
| B | TYR545 |
| B | VAL549 |
| B | TYR877 |
| B | SER880 |
| B | LEU881 |
| B | VAL884 |
| B | MET902 |
| B | VAL905 |
| B | PRO906 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue R16 B 1105 |
| Chain | Residue |
| B | LYS29 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue LMT B 1106 |
| Chain | Residue |
| B | SER530 |
| B | ARG536 |
| B | SER537 |
| B | ARG540 |
| B | TYR541 |
| B | LEU1017 |
| D | ASN41 |
| D | ASP72 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue LMT B 1107 |
| Chain | Residue |
| B | ILE27 |
| B | ASN298 |
| B | ASP301 |
| B | LYS334 |
| B | LEU383 |
| B | SER389 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue PTY C 1101 |
| Chain | Residue |
| B | TRP13 |
| C | GLU893 |
| C | SER894 |
| C | TRP895 |
| C | SER896 |
| C | ARG1030 |
| C | PHE1033 |
| C | SER1034 |
| C | ARG1035 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue LMT C 1102 |
| Chain | Residue |
| C | SER530 |
| C | GLY533 |
| C | ARG536 |
| C | SER537 |
| C | TYR541 |
| C | ILE548 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 1103 |
| Chain | Residue |
| C | GLY691 |
| C | HIS692 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 372 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1932 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 63 |
| Details | Transmembrane: {"description":"Helical; Name=4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 72 |
| Details | Transmembrane: {"description":"Helical; Name=6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=12"} |
| Chain | Residue | Details |
