6ZO9
Binding of two rifabutins to the access pocket of AcrB-G621P T protomer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Multidrug efflux pump subunit AcrB | polymer | 1057 | 114776.4 | 3 | UniProt (P31224) Pfam (PF00873) | Escherichia coli K-12 | AcrAB-TolC multidrug efflux pump subunit AcrB,Acridine resistance protein B |
| 2 | D, E (D, E) | DARPIN | polymer | 169 | 18317.6 | 2 | synthetic construct | ||
| 3 | BA, CA, F (C, A) | DODECANE | non-polymer | 170.3 | 3 | Chemie (D12) | |||
| 4 | DA, EA, G, H, I... (C, A, B) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 6 | Chemie (LMT) | |||
| 5 | FA, GA, J (C, A) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 3 | Chemie (PTY) | |||
| 6 | JA, K, R (C, A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 7 | L, T, U, V (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 8 | N (B) | (2S)-3-hydroxypropane-1,2-diyl didecanoate | non-polymer | 400.6 | 1 | Chemie (DDR) | |||
| 9 | HA, O (C, B) | HEXANE | non-polymer | 86.2 | 2 | Chemie (HEX) | |||
| 10 | IA, P, Q (C, B) | N-OCTANE | non-polymer | 114.2 | 3 | Chemie (OCT) | |||
| 11 | KA, S (C, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 12 | W, X (B) | RIFABUTIN | non-polymer | 847.0 | 2 | Chemie (RBT) | |||
| 13 | Y (C) | TETRADECANE | non-polymer | 198.4 | 1 | Chemie (C14) | |||
| 14 | AA, Z (C) | DECANE | non-polymer | 142.3 | 2 | Chemie (D10) | |||
| 15 | LA (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 16 | MA, NA, OA, PA, QA (A, B, C, D, E) | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 1049 (UniProt: P31224)
| PDB | External Database | Details |
|---|---|---|
| Pro 621 | Gly 621 | engineered mutation |
| Leu 1050 | - | expression tag |
| Glu 1051 | - | expression tag |
| His 1052 | - | expression tag |
| His 1053 | - | expression tag |
| His 1054 | - | expression tag |
| His 1055 | - | expression tag |
| His 1056 | - | expression tag |
| His 1057 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 380964.2 | |
| Non-Polymers* | Number of molecules | 33 |
| Total formula weight | 9621.5 | |
| All* | Total formula weight | 390585.7 |
