6ZO9
Binding of two rifabutins to the access pocket of AcrB-G621P T protomer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0015567 | molecular_function | alkane transmembrane transporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015895 | biological_process | alkane transport |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0042930 | biological_process | enterobactin transport |
| A | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098567 | cellular_component | periplasmic side of plasma membrane |
| A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| A | 1990281 | cellular_component | efflux pump complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0015567 | molecular_function | alkane transmembrane transporter activity |
| B | 0015721 | biological_process | bile acid and bile salt transport |
| B | 0015895 | biological_process | alkane transport |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0042930 | biological_process | enterobactin transport |
| B | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098567 | cellular_component | periplasmic side of plasma membrane |
| B | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| B | 1990281 | cellular_component | efflux pump complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009410 | biological_process | response to xenobiotic stimulus |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0015567 | molecular_function | alkane transmembrane transporter activity |
| C | 0015721 | biological_process | bile acid and bile salt transport |
| C | 0015895 | biological_process | alkane transport |
| C | 0015908 | biological_process | fatty acid transport |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042908 | biological_process | xenobiotic transport |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0042930 | biological_process | enterobactin transport |
| C | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| C | 0046677 | biological_process | response to antibiotic |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0098567 | cellular_component | periplasmic side of plasma membrane |
| C | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| C | 1990281 | cellular_component | efflux pump complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue D12 A 1101 |
| Chain | Residue |
| A | ALA457 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue LMT A 1102 |
| Chain | Residue |
| A | LEU28 |
| A | LYS29 |
| A | VAL32 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue LMT A 1103 |
| Chain | Residue |
| A | GLY440 |
| A | CYS887 |
| A | ALA890 |
| A | LEU891 |
| C | ARG8 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue LMT A 1104 |
| Chain | Residue |
| A | SER530 |
| A | GLY533 |
| A | ARG536 |
| A | ARG540 |
| A | TYR541 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue PTY A 1105 |
| Chain | Residue |
| A | PHE4 |
| A | ILE18 |
| B | GLY440 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 1106 |
| Chain | Residue |
| A | TYR811 |
| E | GLU20 |
| E | ASP44 |
| E | HOH203 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1107 |
| Chain | Residue |
| A | PRO36 |
| A | THR37 |
| A | SER389 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue LMT B 1101 |
| Chain | Residue |
| B | SER530 |
| B | ILE534 |
| B | ARG536 |
| B | SER537 |
| B | TYR541 |
| B | PHE1020 |
| D | ASP72 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue DDR B 1102 |
| Chain | Residue |
| B | VAL452 |
| B | TYR467 |
| B | TYR877 |
| B | SER880 |
| B | GLN928 |
| B | LEU932 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue HEX B 1103 |
| Chain | Residue |
| B | TRP895 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue OCT B 1105 |
| Chain | Residue |
| B | PHE885 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 1106 |
| Chain | Residue |
| A | ALA165 |
| A | ARG168 |
| B | ASN820 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 1107 |
| Chain | Residue |
| B | LYS55 |
| B | GLY691 |
| B | HIS692 |
| B | HOH1203 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1108 |
| Chain | Residue |
| B | SER233 |
| B | HOH1223 |
| C | SER84 |
| C | PRO621 |
| C | PRO814 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1109 |
| Chain | Residue |
| B | THR463 |
| B | GLU866 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1110 |
| Chain | Residue |
| A | PHE316 |
| B | ALA688 |
| B | THR853 |
| B | GLY854 |
| site_id | AD8 |
| Number of Residues | 16 |
| Details | binding site for residue RBT B 1111 |
| Chain | Residue |
| B | MET575 |
| B | PHE664 |
| B | PHE666 |
| B | THR676 |
| B | THR678 |
| B | PHE680 |
| B | ASP681 |
| B | SER715 |
| B | PRO718 |
| B | ASN719 |
| B | GLY720 |
| B | GLU826 |
| B | LEU828 |
| B | GLY829 |
| B | GLN830 |
| B | RBT1112 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue RBT B 1112 |
| Chain | Residue |
| B | MET575 |
| B | PHE617 |
| B | ALA618 |
| B | PHE666 |
| B | PRO669 |
| B | LEU674 |
| B | GLY675 |
| B | ASN719 |
| B | RBT1111 |
| site_id | AE1 |
| Number of Residues | 1 |
| Details | binding site for residue D10 C 1102 |
| Chain | Residue |
| C | ILE935 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue LMT C 1106 |
| Chain | Residue |
| C | SER530 |
| C | ARG536 |
| C | SER537 |
| C | ARG540 |
| C | TYR541 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue LMT C 1107 |
| Chain | Residue |
| C | GLY511 |
| C | PHE512 |
| C | ARG518 |
| site_id | AE4 |
| Number of Residues | 9 |
| Details | binding site for residue PTY C 1108 |
| Chain | Residue |
| C | HOH1215 |
| B | TRP13 |
| C | ILE882 |
| C | SER894 |
| C | TRP895 |
| C | SER896 |
| C | LYS950 |
| C | ARG1030 |
| C | SER1034 |
| site_id | AE5 |
| Number of Residues | 8 |
| Details | binding site for residue PTY C 1109 |
| Chain | Residue |
| B | ARG8 |
| B | PHE11 |
| B | ILE18 |
| C | GLY440 |
| C | MET447 |
| C | LEU891 |
| C | TYR892 |
| C | LYS950 |
| site_id | AE6 |
| Number of Residues | 1 |
| Details | binding site for residue OCT C 1111 |
| Chain | Residue |
| C | SER530 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 1112 |
| Chain | Residue |
| C | LEU564 |
| C | PRO565 |
| C | ASP566 |
| C | SER836 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 1113 |
| Chain | Residue |
| C | LYS55 |
| C | GLY691 |
| C | HIS692 |
| site_id | AE9 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 1114 |
| Chain | Residue |
| C | ARG468 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 372 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1932 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 63 |
| Details | Transmembrane: {"description":"Helical; Name=4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 72 |
| Details | Transmembrane: {"description":"Helical; Name=6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=12"} |
| Chain | Residue | Details |
