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6ZL5

CRYSTAL STRUCTURE OF KRAS-G12D(C118S) IN COMPLEX WITH BI-2852 AND GDP

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
GTPase KRaspolymer17019370.81UniProt (P01116)
Pfam (PF00071)
Homo sapiens (Human)K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2B
(A)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
3C
(A)
GUANOSINE-5'-DIPHOSPHATEnon-polymer443.21Chemie (GDP)
4D
(A)
(3~{S})-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-onenon-polymer516.61Chemie (F0K)
5E
(A)
SULFATE IONnon-polymer96.11Chemie (SO4)
6F
(A)
waterwater18.0183Chemie (HOH)
Sequence modifications
A: 1 - 169 (UniProt: P01116)
PDBExternal DatabaseDetails
Gly 0-expression tag
Asp 12Gly 12engineered mutation
Ser 118Cys 118engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight19370.8
Non-Polymers*Number of molecules4
Total formula weight1080.2
All*Total formula weight20450.9
*Water molecules are not included.

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PDB entries from 2024-11-06

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