Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6ZL5

CRYSTAL STRUCTURE OF KRAS-G12D(C118S) IN COMPLEX WITH BI-2852 AND GDP

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007165biological_processsignal transduction
A0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue MG A 201
ChainResidue
ASER17
AGDP202
AHOH307
AHOH315
AHOH333
AHOH406

site_idAC2
Number of Residues23
Detailsbinding site for residue GDP A 202
ChainResidue
ALYS16
ASER17
AALA18
APHE28
AASP30
AASN116
ALYS117
AASP119
ALEU120
ASER145
AALA146
ALYS147
AMG201
AHOH307
AHOH315
AHOH333
AHOH340
AHOH347
AHOH360
AHOH385
AGLY13
AVAL14
AGLY15

site_idAC3
Number of Residues19
Detailsbinding site for residue F0K A 203
ChainResidue
AMET1
AGLU3
ALYS5
ALEU6
AVAL7
AASP38
ASER39
AARG41
ALYS42
AGLN43
ALEU52
ALEU53
AASP54
ALEU56
ATYR71
ATHR74
AHOH326
AHOH336
AHOH338

site_idAC4
Number of Residues9
Detailsbinding site for residue SO4 A 204
ChainResidue
AILE46
AASP47
AGLN131
AARG135
AHOH350
AHOH357
AHOH405
AHOH409
AHOH412

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140
ChainResidueDetails
AGLY10
AVAL29
AALA59
AASN116

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17
ChainResidueDetails
AMET1

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17
ChainResidueDetails
ATHR2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838
ChainResidueDetails
ALYS104

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486
ChainResidueDetails
ATHR35

223166

PDB entries from 2024-07-31

PDB statisticsPDBj update infoContact PDBjnumon