6ZHE

Cryo-EM structure of DNA-PK dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F	DNA-dependent protein kinase catalytic subunit,DNA-PKcs	polymer	4156	472056.3	2	UniProt (P78527) Pfam (PF20502) Pfam (PF08163) Pfam (PF19704) Pfam (PF02259) Pfam (PF00454) Pfam (PF02260) In PDB	Homo sapiens (Human)	DNA-PKcs,DNPK1,p460
2	B, G	X-ray repair cross-complementing protein 6	polymer	609	69945.0	2	UniProt (P12956) Pfam (PF02037) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) In PDB	Homo sapiens (Human)	5'-deoxyribose-5-phosphate lyase Ku70,5'-dRP lyase Ku70,70 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa subunit,CTCBF,DNA repair protein XRCC6,Lupus Ku autoantigen protein p70,Ku70,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 6
3	C, H	X-ray repair cross-complementing protein 5	polymer	732	82812.4	2	UniProt (P13010) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) Pfam (PF08785) In PDB	Homo sapiens (Human)	86 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box-binding factor 85 kDa subunit,CTCBF,DNA repair protein XRCC5,Ku80,Ku86,Lupus Ku autoantigen protein p86,Nuclear factor IV,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
4	J	DNA (25-MER)	polymer	25	7748.0	1		Homo sapiens
5	I	DNA (27-MER)	polymer	27	8290.4	1		Homo sapiens
6	D	DNA (26-MER)	polymer	26	8037.2	1		Homo sapiens
7	E	DNA (28-MER)	polymer	28	8603.6	1		Homo sapiens

Sequence modifications

A, F: 1 - 4128 (UniProt: P78527)
A, F: 5009 - 6023 (PDB: 6ZHE)

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	1282306.8
All*	Total formula weight	1282306.8

*Water molecules are not included.