6ZFH

Structure of human galactokinase in complex with galactose and 2'-(benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'H-spiro[cyclopentane-1,4'-quinazolin]-5'(6'H)-one

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Galactokinase	polymer	399	43103.0	8	UniProt (P51570) Pfam (PF10509) Pfam (PF00288) Pfam (PF08544)	Homo sapiens (Human)	Galactose kinase
2	I, K, M, O, Q... (A, B, C, D, E...)	beta-D-galactopyranose	non-polymer		180.2	8	Chemie (GAL)
3	J, L, N, P, R... (A, B, C, D, E...)	2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclopentane]-5-one	non-polymer		336.4	7	Chemie (QV2)
4	AA, BA, CA, DA, EA... (D, E, F, G, H...)	water	water		18.0	332	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 2 - 392 (UniProt: P51570)

PDB	External Database	Details
Met -6	-	initiating methionine
Ala -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Ala 252	Lys 252	conflict
Ala 253	Glu 253	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	344823.8
Non-Polymers*	Number of molecules	15
	Total formula weight	3796.0
All*	Total formula weight	348619.8

*Water molecules are not included.