6ZFH
Structure of human galactokinase in complex with galactose and 2'-(benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'H-spiro[cyclopentane-1,4'-quinazolin]-5'(6'H)-one
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Galactokinase | polymer | 399 | 43103.0 | 8 | UniProt (P51570) Pfam (PF10509) Pfam (PF00288) Pfam (PF08544) In PDB | Homo sapiens (Human) | Galactose kinase |
2 | A, B, C, D, E... | beta-D-galactopyranose | non-polymer | 180.2 | 8 | Chemie (GAL) | |||
3 | A, B, C, D, E... | 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclopentane]-5-one | non-polymer | 336.4 | 7 | Chemie (QV2) | |||
4 | water | water | 18.0 | 332 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 2 - 392 (UniProt: P51570)
PDB | External Database | Details |
---|---|---|
Met -6 | - | initiating methionine |
Ala -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
Ala 252 | Lys 252 | conflict |
Ala 253 | Glu 253 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 344823.8 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 3796.0 | |
All* | Total formula weight | 348619.8 |