6ZFH

Structure of human galactokinase in complex with galactose and 2'-(benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'H-spiro[cyclopentane-1,4'-quinazolin]-5'(6'H)-one

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004335	molecular_function	galactokinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005534	molecular_function	galactose binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006012	biological_process	galactose metabolic process
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0019402	biological_process	galactitol metabolic process
A	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
A	0046835	biological_process	carbohydrate phosphorylation
A	0061623	biological_process	glycolytic process from galactose
A	0070062	cellular_component	extracellular exosome
B	0000166	molecular_function	nucleotide binding
B	0004335	molecular_function	galactokinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005534	molecular_function	galactose binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006012	biological_process	galactose metabolic process
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
B	0019402	biological_process	galactitol metabolic process
B	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
B	0046835	biological_process	carbohydrate phosphorylation
B	0061623	biological_process	glycolytic process from galactose
B	0070062	cellular_component	extracellular exosome
C	0000166	molecular_function	nucleotide binding
C	0004335	molecular_function	galactokinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005534	molecular_function	galactose binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006012	biological_process	galactose metabolic process
C	0016020	cellular_component	membrane
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
C	0019402	biological_process	galactitol metabolic process
C	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
C	0046835	biological_process	carbohydrate phosphorylation
C	0061623	biological_process	glycolytic process from galactose
C	0070062	cellular_component	extracellular exosome
D	0000166	molecular_function	nucleotide binding
D	0004335	molecular_function	galactokinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005534	molecular_function	galactose binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006012	biological_process	galactose metabolic process
D	0016020	cellular_component	membrane
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
D	0019402	biological_process	galactitol metabolic process
D	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
D	0046835	biological_process	carbohydrate phosphorylation
D	0061623	biological_process	glycolytic process from galactose
D	0070062	cellular_component	extracellular exosome
E	0000166	molecular_function	nucleotide binding
E	0004335	molecular_function	galactokinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005534	molecular_function	galactose binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006012	biological_process	galactose metabolic process
E	0016020	cellular_component	membrane
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
E	0019402	biological_process	galactitol metabolic process
E	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
E	0046835	biological_process	carbohydrate phosphorylation
E	0061623	biological_process	glycolytic process from galactose
E	0070062	cellular_component	extracellular exosome
F	0000166	molecular_function	nucleotide binding
F	0004335	molecular_function	galactokinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005534	molecular_function	galactose binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006012	biological_process	galactose metabolic process
F	0016020	cellular_component	membrane
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
F	0019402	biological_process	galactitol metabolic process
F	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
F	0046835	biological_process	carbohydrate phosphorylation
F	0061623	biological_process	glycolytic process from galactose
F	0070062	cellular_component	extracellular exosome
G	0000166	molecular_function	nucleotide binding
G	0004335	molecular_function	galactokinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005534	molecular_function	galactose binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006012	biological_process	galactose metabolic process
G	0016020	cellular_component	membrane
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
G	0019402	biological_process	galactitol metabolic process
G	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
G	0046835	biological_process	carbohydrate phosphorylation
G	0061623	biological_process	glycolytic process from galactose
G	0070062	cellular_component	extracellular exosome
H	0000166	molecular_function	nucleotide binding
H	0004335	molecular_function	galactokinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005534	molecular_function	galactose binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006012	biological_process	galactose metabolic process
H	0016020	cellular_component	membrane
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
H	0019402	biological_process	galactitol metabolic process
H	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
H	0046835	biological_process	carbohydrate phosphorylation
H	0061623	biological_process	glycolytic process from galactose
H	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00106
Number of Residues	12
Details	GALACTOKINASE Galactokinase signature. GRvNLIGEHtDY

Chain	Residue	Details
A	GLY36-TYR47

---

site_id	PS00627
Number of Residues	12
Details	GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. VPlGgGLSSSAS

Chain	Residue	Details
A	VAL133-SER144

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"Q9HHB6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	79
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04385","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"Q9HHB6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---