Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ZFH

Structure of human galactokinase in complex with galactose and 2'-(benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'H-spiro[cyclopentane-1,4'-quinazolin]-5'(6'H)-one

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004335	molecular_function	galactokinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005534	molecular_function	galactose binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006012	biological_process	galactose metabolic process
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0019402	biological_process	galactitol metabolic process
A	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
A	0046835	biological_process	carbohydrate phosphorylation
A	0061623	biological_process	glycolytic process from galactose
A	0070062	cellular_component	extracellular exosome
B	0000166	molecular_function	nucleotide binding
B	0004335	molecular_function	galactokinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005534	molecular_function	galactose binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006012	biological_process	galactose metabolic process
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
B	0019402	biological_process	galactitol metabolic process
B	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
B	0046835	biological_process	carbohydrate phosphorylation
B	0061623	biological_process	glycolytic process from galactose
B	0070062	cellular_component	extracellular exosome
C	0000166	molecular_function	nucleotide binding
C	0004335	molecular_function	galactokinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005534	molecular_function	galactose binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006012	biological_process	galactose metabolic process
C	0016020	cellular_component	membrane
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
C	0019402	biological_process	galactitol metabolic process
C	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
C	0046835	biological_process	carbohydrate phosphorylation
C	0061623	biological_process	glycolytic process from galactose
C	0070062	cellular_component	extracellular exosome
D	0000166	molecular_function	nucleotide binding
D	0004335	molecular_function	galactokinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005534	molecular_function	galactose binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006012	biological_process	galactose metabolic process
D	0016020	cellular_component	membrane
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
D	0019402	biological_process	galactitol metabolic process
D	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
D	0046835	biological_process	carbohydrate phosphorylation
D	0061623	biological_process	glycolytic process from galactose
D	0070062	cellular_component	extracellular exosome
E	0000166	molecular_function	nucleotide binding
E	0004335	molecular_function	galactokinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005534	molecular_function	galactose binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006012	biological_process	galactose metabolic process
E	0016020	cellular_component	membrane
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
E	0019402	biological_process	galactitol metabolic process
E	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
E	0046835	biological_process	carbohydrate phosphorylation
E	0061623	biological_process	glycolytic process from galactose
E	0070062	cellular_component	extracellular exosome
F	0000166	molecular_function	nucleotide binding
F	0004335	molecular_function	galactokinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005534	molecular_function	galactose binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006012	biological_process	galactose metabolic process
F	0016020	cellular_component	membrane
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
F	0019402	biological_process	galactitol metabolic process
F	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
F	0046835	biological_process	carbohydrate phosphorylation
F	0061623	biological_process	glycolytic process from galactose
F	0070062	cellular_component	extracellular exosome
G	0000166	molecular_function	nucleotide binding
G	0004335	molecular_function	galactokinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005534	molecular_function	galactose binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006012	biological_process	galactose metabolic process
G	0016020	cellular_component	membrane
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
G	0019402	biological_process	galactitol metabolic process
G	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
G	0046835	biological_process	carbohydrate phosphorylation
G	0061623	biological_process	glycolytic process from galactose
G	0070062	cellular_component	extracellular exosome
H	0000166	molecular_function	nucleotide binding
H	0004335	molecular_function	galactokinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005534	molecular_function	galactose binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006012	biological_process	galactose metabolic process
H	0016020	cellular_component	membrane
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
H	0019402	biological_process	galactitol metabolic process
H	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway
H	0046835	biological_process	carbohydrate phosphorylation
H	0061623	biological_process	glycolytic process from galactose
H	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00106
Number of Residues	12
Details	GALACTOKINASE Galactokinase signature. GRvNLIGEHtDY

Chain	Residue	Details
A	GLY36-TYR47

site_id	PS00627
Number of Residues	12
Details	GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. VPlGgGLSSSAS

Chain	Residue	Details
A	VAL133-SER144

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000250\|UniProtKB:Q9HHB6

Chain	Residue	Details
A	ASP186
B	ASP186
C	ASP186
D	ASP186
E	ASP186
F	ASP186
G	ASP186
H	ASP186

site_id	SWS_FT_FI2
Number of Residues	80
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P04385

Chain	Residue	Details
A	ARG37
A	TYR236
B	ARG37
B	GLU43
B	HIS44
B	ASP46
B	GLY136
B	GLY138
B	SER140
B	SER141
B	ASP186
A	GLU43
B	TYR236
C	ARG37
C	GLU43
C	HIS44
C	ASP46
C	GLY136
C	GLY138
C	SER140
C	SER141
C	ASP186
A	HIS44
C	TYR236
D	ARG37
D	GLU43
D	HIS44
D	ASP46
D	GLY136
D	GLY138
D	SER140
D	SER141
D	ASP186
A	ASP46
D	TYR236
E	ARG37
E	GLU43
E	HIS44
E	ASP46
E	GLY136
E	GLY138
E	SER140
E	SER141
E	ASP186
A	GLY136
E	TYR236
F	ARG37
F	GLU43
F	HIS44
F	ASP46
F	GLY136
F	GLY138
F	SER140
F	SER141
F	ASP186
A	GLY138
F	TYR236
G	ARG37
G	GLU43
G	HIS44
G	ASP46
G	GLY136
G	GLY138
G	SER140
G	SER141
G	ASP186
A	SER140
G	TYR236
H	ARG37
H	GLU43
H	HIS44
H	ASP46
H	GLY136
H	GLY138
H	SER140
H	SER141
H	ASP186
A	SER141
H	TYR236
A	ASP186

site_id	SWS_FT_FI3
Number of Residues	8
Details	SITE: Transition state stabilizer => ECO:0000250\|UniProtKB:Q9HHB6

Chain	Residue	Details
A	ARG37
B	ARG37
C	ARG37
D	ARG37
E	ARG37
F	ARG37
G	ARG37
H	ARG37

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER230
B	SER230
C	SER230
D	SER230
E	SER230
F	SER230
G	SER230
H	SER230

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)