6ZF3
Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Kelch-like ECH-associated protein 1 | polymer | 304 | 33362.3 | 1 | UniProt (Q9Z2X8) Pfam (PF01344) | Mus musculus (Mouse) | Cytosolic inhibitor of Nrf2,INrf2 |
| 2 | B (A) | ~{N}-[3-[5-cyclopropyl-4-(2~{H}-1,2,3,4-tetrazol-5-yl)pyrazol-1-yl]phenyl]benzenesulfonamide | non-polymer | 407.4 | 1 | Chemie (QH5) | |||
| 3 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F, G, H, I, J... (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 12 | Chemie (DMS) | |||
| 5 | R (A) | water | water | 18.0 | 221 | Chemie (HOH) |
Sequence modifications
A: 322 - 624 (UniProt: Q9Z2X8)
| PDB | External Database | Details |
|---|---|---|
| Gly 321 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33362.3 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1633.2 | |
| All* | Total formula weight | 34995.5 |
