6ZF3

Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008134	molecular_function	transcription factor binding
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue QH5 A 1101

Chain	Residue
A	TYR334
A	SER602
A	GLY603
A	SO41104
A	DMS1111
A	DMS1112
A	HOH1269
A	GLY364
A	ARG415
A	GLY462
A	ARG483
A	SER508
A	TYR525
A	SER555
A	ALA556

---

site_id	AC2
Number of Residues	8
Details	binding site for residue SO4 A 1102

Chain	Residue
A	CYS434
A	HIS436
A	ARG459
A	ARG494
A	ARG498
A	HOH1246
A	HOH1258
A	HOH1403

---

site_id	AC3
Number of Residues	10
Details	binding site for residue SO4 A 1103

Chain	Residue
A	ILE435
A	HIS437
A	SER438
A	SER439
A	ARG494
A	HOH1206
A	HOH1273
A	HOH1274
A	HOH1337
A	HOH1404

---

site_id	AC4
Number of Residues	7
Details	binding site for residue SO4 A 1104

Chain	Residue
A	ASN382
A	ASN414
A	ARG415
A	QH51101
A	HOH1201
A	HOH1204
A	HOH1205

---

site_id	AC5
Number of Residues	3
Details	binding site for residue DMS A 1105

Chain	Residue
A	HIS451
A	LEU452
A	HOH1203

---

site_id	AC6
Number of Residues	5
Details	binding site for residue DMS A 1106

Chain	Residue
A	ILE421
A	HIS424
A	TYR426
A	ARG442
A	PRO492

---

site_id	AC7
Number of Residues	3
Details	binding site for residue DMS A 1107

Chain	Residue
A	ALA407
A	SER408
A	HOH1288

---

site_id	AC8
Number of Residues	2
Details	binding site for residue DMS A 1108

Chain	Residue
A	ARG494
A	ASN495

---

site_id	AC9
Number of Residues	3
Details	binding site for residue DMS A 1109

Chain	Residue
A	ARG459
A	HOH1277
A	HOH1403

---

site_id	AD1
Number of Residues	1
Details	binding site for residue DMS A 1110

Chain	Residue
A	ARG442

---

site_id	AD2
Number of Residues	4
Details	binding site for residue DMS A 1111

Chain	Residue
A	ARG415
A	PHE478
A	QH51101
A	DMS1114

---

site_id	AD3
Number of Residues	5
Details	binding site for residue DMS A 1112

Chain	Residue
A	TYR525
A	GLN530
A	SER555
A	TYR572
A	QH51101

---

site_id	AD4
Number of Residues	3
Details	binding site for residue DMS A 1113

Chain	Residue
A	CYS368
A	VAL369
A	HOH1313

---

site_id	AD5
Number of Residues	2
Details	binding site for residue DMS A 1114

Chain	Residue
A	ARG483
A	DMS1111

---

site_id	AD6
Number of Residues	5
Details	binding site for residue DMS A 1115

Chain	Residue
A	PHE546
A	GLN563
A	HOH1268
A	HOH1340
A	HOH1415

---

site_id	AD7
Number of Residues	5
Details	binding site for residue DMS A 1116

Chain	Residue
A	SER438
A	LEU457
A	THR458
A	ARG459
A	HOH1274

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	45
Details	Repeat: {"description":"Kelch 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	50
Details	Repeat: {"description":"Kelch 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	46
Details	Repeat: {"description":"Kelch 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	46
Details	Repeat: {"description":"Kelch 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	45
Details	Repeat: {"description":"Kelch 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	46
Details	Repeat: {"description":"Kelch 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---