6ZF2
Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Kelch-like ECH-associated protein 1 | polymer | 304 | 33362.3 | 1 | UniProt (Q9Z2X8) Pfam (PF01344) | Mus musculus (House mouse) | Cytosolic inhibitor of Nrf2,INrf2 |
| 2 | B, C, D, E (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 3 | F (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | G (A) | 5-cyclopropyl-1-[3-[(4-propylphenyl)sulfonylamino]phenyl]pyrazole-4-carboxylic acid | non-polymer | 425.5 | 1 | Chemie (QJ5) | |||
| 5 | H (A) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A: 322 - 624 (UniProt: Q9Z2X8)
| PDB | External Database | Details |
|---|---|---|
| Gly 321 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33362.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 834.1 | |
| All* | Total formula weight | 34196.4 |
