6ZF2

Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008134	molecular_function	transcription factor binding
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue DMS A 701

Chain	Residue
A	VAL453
A	ALA454
A	ASN495

---

site_id	AC2
Number of Residues	2
Details	binding site for residue DMS A 702

Chain	Residue
A	SER438
A	ARG459

---

site_id	AC3
Number of Residues	4
Details	binding site for residue DMS A 703

Chain	Residue
A	ARG415
A	PHE478
A	ARG483
A	QJ5706

---

site_id	AC4
Number of Residues	4
Details	binding site for residue DMS A 704

Chain	Residue
A	TYR525
A	GLN530
A	SER555
A	QJ5706

---

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 A 705

Chain	Residue
A	HIS436
A	HIS437
A	SER438
A	SER439
A	ARG494
A	HOH804

---

site_id	AC6
Number of Residues	12
Details	binding site for residue QJ5 A 706

Chain	Residue
A	TYR334
A	SER363
A	ARG415
A	GLY462
A	ARG483
A	SER508
A	ALA556
A	TYR572
A	SER602
A	GLY603
A	DMS703
A	DMS704

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	45
Details	Repeat: {"description":"Kelch 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	50
Details	Repeat: {"description":"Kelch 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	46
Details	Repeat: {"description":"Kelch 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	46
Details	Repeat: {"description":"Kelch 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	45
Details	Repeat: {"description":"Kelch 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	46
Details	Repeat: {"description":"Kelch 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---