6ZDM
Crystal structure of human heparanase in complex with a N',6O'-bis-sulfated 4-methylumbelliferyl heparan sulfate disaccharide
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | AAA | Heparanase | polymer | 389 | 43733.3 | 1 | UniProt (Q9Y251) Pfam (PF03662) In PDB | Homo sapiens (Human) | Endo-glucoronidase,Heparanase-1,Hpa1 |
2 | BBB | Heparanase | polymer | 77 | 8542.8 | 1 | UniProt (Q9Y251) In PDB | Homo sapiens (Human) | Endo-glucoronidase,Heparanase-1,Hpa1 |
3 | AAA | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
4 | AAA | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
5 | AAA | (2~{S},3~{S},4~{R},5~{R},6~{S})-3-[(2~{R},3~{R},4~{R},5~{S},6~{R})-4,5-bis(oxidanyl)-3-(sulfoamino)-6-(sulfooxymethyl)oxan-2-yl]oxy-6-(4-methyl-2-oxidanylidene-chromen-7-yl)oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid | non-polymer | 673.6 | 1 | Chemie (QG2) | |||
6 | AAA | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
7 | water | water | 18.0 | 191 | Chemie (HOH) |
Sequence modifications
AAA: 158 - 543 (UniProt: Q9Y251)
BBB: 1 - 74 (UniProt: Q9Y251)
PDB | External Database | Details |
---|---|---|
Asp 155 | - | expression tag |
Pro 156 | - | expression tag |
Gly 157 | - | expression tag |
Arg 307 | Lys 307 | conflict |
PDB | External Database | Details |
---|---|---|
Asp -2 | - | expression tag |
Pro -1 | - | expression tag |
Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 52276.1 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1437.2 | |
All* | Total formula weight | 53713.3 |