6ZCP
SYK Kinase domain in complex with azabenzimidazole inhibitor 2b
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase SYK | polymer | 299 | 34881.0 | 1 | UniProt (P43405) Pfam (PF07714) In PDB | Homo sapiens (Human) | Spleen tyrosine kinase,p72-Syk |
2 | A | 7-[[4-[4-[(dimethylamino)methyl]pyrazol-1-yl]pyrimidin-2-yl]amino]-~{N},3-dimethyl-imidazo[1,5-a]pyridine-1-carboxamide | non-polymer | 405.5 | 1 | Chemie (QFK) | |||
3 | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 343 - 635 (UniProt: P43405)
PDB | External Database | Details |
---|---|---|
His 636 | - | expression tag |
His 637 | - | expression tag |
His 638 | - | expression tag |
His 639 | - | expression tag |
His 640 | - | expression tag |
His 641 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34881.0 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 405.5 | |
All* | Total formula weight | 35286.4 |