6ZC6
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Segment polarity protein dishevelled homolog DVL-3 | polymer | 95 | 10199.7 | 1 | UniProt (Q92997) Pfam (PF00595) | Homo sapiens (Human) | Dishevelled-3,DSH homolog 3 |
| 2 | B, C (A) | 5-bromanyl-2-(naphthalen-2-ylsulfonylamino)benzoic acid | non-polymer | 406.3 | 2 | Chemie (QEN) | |||
| 3 | D, E, F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | G (A) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A: 243 - 335 (UniProt: Q92997)
| PDB | External Database | Details |
|---|---|---|
| Ala 242 | - | expression tag |
| Ser 336 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 10199.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 998.7 | |
| All* | Total formula weight | 11198.4 |
