6ZC4
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dishevelled, dsh homolog 3 (Drosophila), isoform CRA_b | polymer | 95 | 10199.7 | 2 | UniProt (Q9UG07) Pfam (PF00595) UniProt (by SIFTS) (Q92997) | Homo sapiens (Human) | |
| 2 | C, D (A, B) | 5-bromanyl-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)benzoic acid | non-polymer | 410.3 | 2 | Chemie (QEZ) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A, B: 243 - 335 (UniProt: Q9UG07)
| PDB | External Database | Details |
|---|---|---|
| Ala 242 | - | expression tag |
| Ser 336 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 20399.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 820.6 | |
| All* | Total formula weight | 21219.9 |
