6ZC0
SYK Kinase domain in complex with azabenzimidazole inhibitor 2b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase SYK | polymer | 299 | 34881.0 | 1 | UniProt (P43405) Pfam (PF07714) | Homo sapiens (Human) | Spleen tyrosine kinase,p72-Syk |
| 2 | B (A) | ~{N},~{N}-dimethyl-1-[1-[2-(1-methylindol-4-yl)-3~{H}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]methanamine | non-polymer | 371.4 | 1 | Chemie (QDZ) | |||
| 3 | C (A) | water | water | 18.0 | 124 | Chemie (HOH) |
Sequence modifications
A: 343 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| His 636 | - | expression tag |
| His 637 | - | expression tag |
| His 638 | - | expression tag |
| His 639 | - | expression tag |
| His 640 | - | expression tag |
| His 641 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34881.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 371.4 | |
| All* | Total formula weight | 35252.4 |
