6Z80

stimulatory human GTP cyclohydrolase I - GFRP complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, E, G...	GTP cyclohydrolase 1	polymer	224	25324.9	10	UniProt (P30793) Pfam (PF01227) In PDB	Homo sapiens (Human)	GTP cyclohydrolase I,GTP-CH-I
2	L, K, N, M, O...	GTP cyclohydrolase 1 feedback regulatory protein	polymer	87	9992.5	10	UniProt (P30047) Pfam (PF06399) In PDB	Homo sapiens (Human)	GFRP,GTP cyclohydrolase I feedback regulatory protein,p35
3	E, G, H, I, J...	ZINC ION	non-polymer		65.4	10	Chemie (ZN)
4	K, N, M, O, P...	PHENYLALANINE	non-polymer		165.2	10	Chemie (PHE)
5	E, H, I, J, F...	8-OXO-GUANOSINE-5'-TRIPHOSPHATE	non-polymer		539.2	10	Chemie (8GT)

Sequence modifications

A, B, C, E, G, H, I, J, F, D: 41 - 250 (UniProt: P30793)

PDB	External Database	Details
Met 27	-	initiating methionine
His 28	-	expression tag
His 29	-	expression tag
His 30	-	expression tag
His 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
Gly 34	-	expression tag
Ser 35	-	expression tag
Asp 36	-	expression tag
Asp 37	-	expression tag
Asp 38	-	expression tag
Asp 39	-	expression tag
Lys 40	-	expression tag

L, K, N, M, O, P, Q, R, S, T: 1 - 84 (UniProt: P30047)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	20
	Total formula weight	353174.0
Non-Polymers*	Number of molecules	30
	Total formula weight	7697.8
All*	Total formula weight	360871.8

*Water molecules are not included.