Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Z80

stimulatory human GTP cyclohydrolase I - GFRP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0003934	molecular_function	GTP cyclohydrolase I activity
F	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0003934	molecular_function	GTP cyclohydrolase I activity
G	0046654	biological_process	tetrahydrofolate biosynthetic process
H	0003934	molecular_function	GTP cyclohydrolase I activity
H	0046654	biological_process	tetrahydrofolate biosynthetic process
I	0003934	molecular_function	GTP cyclohydrolase I activity
I	0046654	biological_process	tetrahydrofolate biosynthetic process
J	0003934	molecular_function	GTP cyclohydrolase I activity
J	0046654	biological_process	tetrahydrofolate biosynthetic process
K	0004857	molecular_function	enzyme inhibitor activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0009890	biological_process	negative regulation of biosynthetic process
K	0016020	cellular_component	membrane
K	0030425	cellular_component	dendrite
K	0031965	cellular_component	nuclear membrane
K	0042470	cellular_component	melanosome
K	0044549	molecular_function	GTP cyclohydrolase binding
K	0045428	biological_process	regulation of nitric oxide biosynthetic process
K	0060308	molecular_function	GTP cyclohydrolase I regulator activity
K	0062014	biological_process	negative regulation of small molecule metabolic process
L	0004857	molecular_function	enzyme inhibitor activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0009890	biological_process	negative regulation of biosynthetic process
L	0016020	cellular_component	membrane
L	0030425	cellular_component	dendrite
L	0031965	cellular_component	nuclear membrane
L	0042470	cellular_component	melanosome
L	0044549	molecular_function	GTP cyclohydrolase binding
L	0045428	biological_process	regulation of nitric oxide biosynthetic process
L	0060308	molecular_function	GTP cyclohydrolase I regulator activity
L	0062014	biological_process	negative regulation of small molecule metabolic process
M	0004857	molecular_function	enzyme inhibitor activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0009890	biological_process	negative regulation of biosynthetic process
M	0016020	cellular_component	membrane
M	0030425	cellular_component	dendrite
M	0031965	cellular_component	nuclear membrane
M	0042470	cellular_component	melanosome
M	0044549	molecular_function	GTP cyclohydrolase binding
M	0045428	biological_process	regulation of nitric oxide biosynthetic process
M	0060308	molecular_function	GTP cyclohydrolase I regulator activity
M	0062014	biological_process	negative regulation of small molecule metabolic process
N	0004857	molecular_function	enzyme inhibitor activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0009890	biological_process	negative regulation of biosynthetic process
N	0016020	cellular_component	membrane
N	0030425	cellular_component	dendrite
N	0031965	cellular_component	nuclear membrane
N	0042470	cellular_component	melanosome
N	0044549	molecular_function	GTP cyclohydrolase binding
N	0045428	biological_process	regulation of nitric oxide biosynthetic process
N	0060308	molecular_function	GTP cyclohydrolase I regulator activity
N	0062014	biological_process	negative regulation of small molecule metabolic process
O	0004857	molecular_function	enzyme inhibitor activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0009890	biological_process	negative regulation of biosynthetic process
O	0016020	cellular_component	membrane
O	0030425	cellular_component	dendrite
O	0031965	cellular_component	nuclear membrane
O	0042470	cellular_component	melanosome
O	0044549	molecular_function	GTP cyclohydrolase binding
O	0045428	biological_process	regulation of nitric oxide biosynthetic process
O	0060308	molecular_function	GTP cyclohydrolase I regulator activity
O	0062014	biological_process	negative regulation of small molecule metabolic process
P	0004857	molecular_function	enzyme inhibitor activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0009890	biological_process	negative regulation of biosynthetic process
P	0016020	cellular_component	membrane
P	0030425	cellular_component	dendrite
P	0031965	cellular_component	nuclear membrane
P	0042470	cellular_component	melanosome
P	0044549	molecular_function	GTP cyclohydrolase binding
P	0045428	biological_process	regulation of nitric oxide biosynthetic process
P	0060308	molecular_function	GTP cyclohydrolase I regulator activity
P	0062014	biological_process	negative regulation of small molecule metabolic process
Q	0004857	molecular_function	enzyme inhibitor activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0009890	biological_process	negative regulation of biosynthetic process
Q	0016020	cellular_component	membrane
Q	0030425	cellular_component	dendrite
Q	0031965	cellular_component	nuclear membrane
Q	0042470	cellular_component	melanosome
Q	0044549	molecular_function	GTP cyclohydrolase binding
Q	0045428	biological_process	regulation of nitric oxide biosynthetic process
Q	0060308	molecular_function	GTP cyclohydrolase I regulator activity
Q	0062014	biological_process	negative regulation of small molecule metabolic process
R	0004857	molecular_function	enzyme inhibitor activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0009890	biological_process	negative regulation of biosynthetic process
R	0016020	cellular_component	membrane
R	0030425	cellular_component	dendrite
R	0031965	cellular_component	nuclear membrane
R	0042470	cellular_component	melanosome
R	0044549	molecular_function	GTP cyclohydrolase binding
R	0045428	biological_process	regulation of nitric oxide biosynthetic process
R	0060308	molecular_function	GTP cyclohydrolase I regulator activity
R	0062014	biological_process	negative regulation of small molecule metabolic process
S	0004857	molecular_function	enzyme inhibitor activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0009890	biological_process	negative regulation of biosynthetic process
S	0016020	cellular_component	membrane
S	0030425	cellular_component	dendrite
S	0031965	cellular_component	nuclear membrane
S	0042470	cellular_component	melanosome
S	0044549	molecular_function	GTP cyclohydrolase binding
S	0045428	biological_process	regulation of nitric oxide biosynthetic process
S	0060308	molecular_function	GTP cyclohydrolase I regulator activity
S	0062014	biological_process	negative regulation of small molecule metabolic process
T	0004857	molecular_function	enzyme inhibitor activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0009890	biological_process	negative regulation of biosynthetic process
T	0016020	cellular_component	membrane
T	0030425	cellular_component	dendrite
T	0031965	cellular_component	nuclear membrane
T	0042470	cellular_component	melanosome
T	0044549	molecular_function	GTP cyclohydrolase binding
T	0045428	biological_process	regulation of nitric oxide biosynthetic process
T	0060308	molecular_function	GTP cyclohydrolase I regulator activity
T	0062014	biological_process	negative regulation of small molecule metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	CYS141
A	HIS144
A	CYS212
B	8GT301

site_id	AC2
Number of Residues	5
Details	binding site for residue PHE L 101

Chain	Residue
C	GLU236
L	GLN9
L	ILE10
L	GLN75
M	VAL73

site_id	AC3
Number of Residues	17
Details	binding site for residue 8GT B 301

Chain	Residue
A	CYS141
A	HIS143
A	HIS144
A	VAL181
A	GLN182
A	GLU183
A	HIS210
A	CYS212
A	ARG216
A	ZN301
B	LEU163
B	GLY164
B	LEU165
B	SER166
B	LYS167
B	ARG170
F	ARG97

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 302

Chain	Residue
B	CYS141
B	HIS144
B	CYS212
C	8GT301

site_id	AC5
Number of Residues	17
Details	binding site for residue 8GT C 301

Chain	Residue
B	CYS141
B	HIS143
B	HIS144
B	VAL181
B	GLN182
B	GLU183
B	HIS210
B	CYS212
B	ARG216
B	ZN302
C	LEU163
C	GLY164
C	LEU165
C	SER166
C	LYS167
C	ARG170
J	ARG97

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN C 302

Chain	Residue
C	CYS141
C	HIS144
C	CYS212
D	8GT302

site_id	AC7
Number of Residues	17
Details	binding site for residue 8GT E 301

Chain	Residue
A	LEU163
A	GLY164
A	LEU165
A	SER166
A	LYS167
A	ARG170
E	CYS141
E	HIS143
E	HIS144
E	VAL181
E	GLN182
E	GLU183
E	HIS210
E	CYS212
E	ARG216
E	ZN302
G	ARG97

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN E 302

Chain	Residue
E	CYS141
E	HIS144
E	CYS212
E	8GT301

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN G 301

Chain	Residue
G	CYS141
G	HIS144
G	CYS212
H	8GT301

site_id	AD1
Number of Residues	17
Details	binding site for residue 8GT H 301

Chain	Residue
E	ARG97
G	CYS141
G	HIS143
G	HIS144
G	VAL181
G	GLN182
G	GLU183
G	HIS210
G	CYS212
G	ARG216
G	ZN301
H	LEU163
H	GLY164
H	LEU165
H	SER166
H	LYS167
H	ARG170

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN H 302

Chain	Residue
H	CYS141
H	HIS144
H	CYS212
I	8GT301

site_id	AD3
Number of Residues	17
Details	binding site for residue 8GT I 301

Chain	Residue
H	HIS143
H	HIS144
H	VAL181
H	GLN182
H	GLU183
H	HIS210
H	CYS212
H	ARG216
H	ZN302
I	LEU163
I	GLY164
I	LEU165
I	SER166
I	LYS167
I	ARG170
D	ARG97
H	CYS141

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN I 302

Chain	Residue
I	CYS141
I	HIS144
I	CYS212
J	8GT301

site_id	AD5
Number of Residues	17
Details	binding site for residue 8GT J 301

Chain	Residue
C	ARG97
I	CYS141
I	HIS143
I	HIS144
I	VAL181
I	GLN182
I	GLU183
I	HIS210
I	CYS212
I	ARG216
I	ZN302
J	LEU163
J	GLY164
J	LEU165
J	SER166
J	LYS167
J	ARG170

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN J 302

Chain	Residue
F	8GT302
J	CYS141
J	HIS144
J	CYS212

site_id	AD7
Number of Residues	17
Details	binding site for residue 8GT F 301

Chain	Residue
A	ARG97
F	CYS141
F	HIS143
F	HIS144
F	VAL181
F	GLN182
F	GLU183
F	HIS210
F	CYS212
F	ARG216
F	ZN303
G	LEU163
G	GLY164
G	LEU165
G	SER166
G	LYS167
G	ARG170

site_id	AD8
Number of Residues	17
Details	binding site for residue 8GT F 302

Chain	Residue
B	ARG97
F	LEU163
F	GLY164
F	LEU165
F	SER166
F	LYS167
F	ARG170
J	CYS141
J	HIS143
J	HIS144
J	VAL181
J	GLN182
J	GLU183
J	HIS210
J	CYS212
J	ARG216
J	ZN302

site_id	AD9
Number of Residues	4
Details	binding site for residue ZN F 303

Chain	Residue
F	CYS141
F	HIS144
F	CYS212
F	8GT301

site_id	AE1
Number of Residues	17
Details	binding site for residue 8GT D 301

Chain	Residue
D	CYS141
D	HIS143
D	HIS144
D	VAL181
D	GLN182
D	GLU183
D	HIS210
D	CYS212
D	ARG216
D	ZN303
E	LEU163
E	GLY164
E	LEU165
E	SER166
E	LYS167
E	ARG170
H	ARG97

site_id	AE2
Number of Residues	17
Details	binding site for residue 8GT D 302

Chain	Residue
C	CYS141
C	HIS143
C	HIS144
C	VAL181
C	GLN182
C	GLU183
C	HIS210
C	CYS212
C	ARG216
C	ZN302
D	LEU163
D	GLY164
D	LEU165
D	SER166
D	LYS167
D	ARG170
I	ARG97

site_id	AE3
Number of Residues	4
Details	binding site for residue ZN D 303

Chain	Residue
D	CYS141
D	HIS144
D	CYS212
D	8GT301

site_id	AE4
Number of Residues	5
Details	binding site for residue PHE K 101

Chain	Residue
B	GLU236
K	GLN9
K	ILE10
K	GLN75
L	VAL73

site_id	AE5
Number of Residues	5
Details	binding site for residue PHE N 101

Chain	Residue
E	GLU236
N	GLN9
N	ILE10
N	GLN75
O	VAL73

site_id	AE6
Number of Residues	5
Details	binding site for residue PHE M 101

Chain	Residue
D	GLU236
M	GLN9
M	ILE10
M	GLN75
N	VAL73

site_id	AE7
Number of Residues	5
Details	binding site for residue PHE O 101

Chain	Residue
A	GLU236
K	VAL73
O	GLN9
O	ILE10
O	GLN75

site_id	AE8
Number of Residues	5
Details	binding site for residue PHE P 101

Chain	Residue
G	GLU236
P	GLN9
P	ILE10
P	GLN75
Q	VAL73

site_id	AE9
Number of Residues	5
Details	binding site for residue PHE Q 101

Chain	Residue
H	GLU236
Q	GLN9
Q	ILE10
Q	GLN75
R	VAL73

site_id	AF1
Number of Residues	5
Details	binding site for residue PHE R 101

Chain	Residue
I	GLU236
R	GLN9
R	ILE10
R	GLN75
S	VAL73

site_id	AF2
Number of Residues	5
Details	binding site for residue PHE S 101

Chain	Residue
J	GLU236
S	GLN9
S	ILE10
S	GLN75
T	VAL73

site_id	AF3
Number of Residues	5
Details	binding site for residue PHE T 101

Chain	Residue
F	GLU236
P	VAL73
T	GLN9
T	ILE10
T	GLN75

Functional Information from PROSITE/UniProt

site_id	PS00859
Number of Residues	17
Details	GTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. EMVivKDIdmfSmCEHH

Chain	Residue	Details
A	GLU128-HIS144

site_id	PS00860
Number of Residues	11
Details	GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. SrRlQVQERLT

Chain	Residue	Details
A	SER176-THR186

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	BINDING: BINDING => ECO:0000269\|PubMed:11087827

Chain	Residue	Details
A	CYS141
E	CYS141
E	HIS144
E	CYS212
G	CYS141
G	HIS144
G	CYS212
H	CYS141
H	HIS144
H	CYS212
I	CYS141
A	HIS144
I	HIS144
I	CYS212
J	CYS141
J	HIS144
J	CYS212
F	CYS141
F	HIS144
F	CYS212
D	CYS141
D	HIS144
A	CYS212
D	CYS212
B	CYS141
B	HIS144
B	CYS212
C	CYS141
C	HIS144
C	CYS212

site_id	SWS_FT_FI2
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19690332

Chain	Residue	Details
A	SER60
D	SER60
B	SER60
C	SER60
E	SER60
G	SER60
H	SER60
I	SER60
J	SER60
F	SER60

site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:17704208

Chain	Residue	Details
A	SER81
D	SER81
B	SER81
C	SER81
E	SER81
G	SER81
H	SER81
I	SER81
J	SER81
F	SER81

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)