6Z80
stimulatory human GTP cyclohydrolase I - GFRP complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003934 | molecular_function | GTP cyclohydrolase I activity |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0003934 | molecular_function | GTP cyclohydrolase I activity |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
C | 0003934 | molecular_function | GTP cyclohydrolase I activity |
C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
D | 0003934 | molecular_function | GTP cyclohydrolase I activity |
D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
E | 0003934 | molecular_function | GTP cyclohydrolase I activity |
E | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
F | 0003934 | molecular_function | GTP cyclohydrolase I activity |
F | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
G | 0003934 | molecular_function | GTP cyclohydrolase I activity |
G | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
H | 0003934 | molecular_function | GTP cyclohydrolase I activity |
H | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
I | 0003934 | molecular_function | GTP cyclohydrolase I activity |
I | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
J | 0003934 | molecular_function | GTP cyclohydrolase I activity |
J | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
K | 0005515 | molecular_function | protein binding |
K | 0005634 | cellular_component | nucleus |
K | 0005654 | cellular_component | nucleoplasm |
K | 0005737 | cellular_component | cytoplasm |
K | 0005829 | cellular_component | cytosol |
K | 0009890 | biological_process | negative regulation of biosynthetic process |
K | 0016020 | cellular_component | membrane |
K | 0030425 | cellular_component | dendrite |
K | 0031965 | cellular_component | nuclear membrane |
K | 0042470 | cellular_component | melanosome |
K | 0044549 | molecular_function | GTP cyclohydrolase binding |
K | 0045428 | biological_process | regulation of nitric oxide biosynthetic process |
L | 0005515 | molecular_function | protein binding |
L | 0005634 | cellular_component | nucleus |
L | 0005654 | cellular_component | nucleoplasm |
L | 0005737 | cellular_component | cytoplasm |
L | 0005829 | cellular_component | cytosol |
L | 0009890 | biological_process | negative regulation of biosynthetic process |
L | 0016020 | cellular_component | membrane |
L | 0030425 | cellular_component | dendrite |
L | 0031965 | cellular_component | nuclear membrane |
L | 0042470 | cellular_component | melanosome |
L | 0044549 | molecular_function | GTP cyclohydrolase binding |
L | 0045428 | biological_process | regulation of nitric oxide biosynthetic process |
M | 0005515 | molecular_function | protein binding |
M | 0005634 | cellular_component | nucleus |
M | 0005654 | cellular_component | nucleoplasm |
M | 0005737 | cellular_component | cytoplasm |
M | 0005829 | cellular_component | cytosol |
M | 0009890 | biological_process | negative regulation of biosynthetic process |
M | 0016020 | cellular_component | membrane |
M | 0030425 | cellular_component | dendrite |
M | 0031965 | cellular_component | nuclear membrane |
M | 0042470 | cellular_component | melanosome |
M | 0044549 | molecular_function | GTP cyclohydrolase binding |
M | 0045428 | biological_process | regulation of nitric oxide biosynthetic process |
N | 0005515 | molecular_function | protein binding |
N | 0005634 | cellular_component | nucleus |
N | 0005654 | cellular_component | nucleoplasm |
N | 0005737 | cellular_component | cytoplasm |
N | 0005829 | cellular_component | cytosol |
N | 0009890 | biological_process | negative regulation of biosynthetic process |
N | 0016020 | cellular_component | membrane |
N | 0030425 | cellular_component | dendrite |
N | 0031965 | cellular_component | nuclear membrane |
N | 0042470 | cellular_component | melanosome |
N | 0044549 | molecular_function | GTP cyclohydrolase binding |
N | 0045428 | biological_process | regulation of nitric oxide biosynthetic process |
O | 0005515 | molecular_function | protein binding |
O | 0005634 | cellular_component | nucleus |
O | 0005654 | cellular_component | nucleoplasm |
O | 0005737 | cellular_component | cytoplasm |
O | 0005829 | cellular_component | cytosol |
O | 0009890 | biological_process | negative regulation of biosynthetic process |
O | 0016020 | cellular_component | membrane |
O | 0030425 | cellular_component | dendrite |
O | 0031965 | cellular_component | nuclear membrane |
O | 0042470 | cellular_component | melanosome |
O | 0044549 | molecular_function | GTP cyclohydrolase binding |
O | 0045428 | biological_process | regulation of nitric oxide biosynthetic process |
P | 0005515 | molecular_function | protein binding |
P | 0005634 | cellular_component | nucleus |
P | 0005654 | cellular_component | nucleoplasm |
P | 0005737 | cellular_component | cytoplasm |
P | 0005829 | cellular_component | cytosol |
P | 0009890 | biological_process | negative regulation of biosynthetic process |
P | 0016020 | cellular_component | membrane |
P | 0030425 | cellular_component | dendrite |
P | 0031965 | cellular_component | nuclear membrane |
P | 0042470 | cellular_component | melanosome |
P | 0044549 | molecular_function | GTP cyclohydrolase binding |
P | 0045428 | biological_process | regulation of nitric oxide biosynthetic process |
Q | 0005515 | molecular_function | protein binding |
Q | 0005634 | cellular_component | nucleus |
Q | 0005654 | cellular_component | nucleoplasm |
Q | 0005737 | cellular_component | cytoplasm |
Q | 0005829 | cellular_component | cytosol |
Q | 0009890 | biological_process | negative regulation of biosynthetic process |
Q | 0016020 | cellular_component | membrane |
Q | 0030425 | cellular_component | dendrite |
Q | 0031965 | cellular_component | nuclear membrane |
Q | 0042470 | cellular_component | melanosome |
Q | 0044549 | molecular_function | GTP cyclohydrolase binding |
Q | 0045428 | biological_process | regulation of nitric oxide biosynthetic process |
R | 0005515 | molecular_function | protein binding |
R | 0005634 | cellular_component | nucleus |
R | 0005654 | cellular_component | nucleoplasm |
R | 0005737 | cellular_component | cytoplasm |
R | 0005829 | cellular_component | cytosol |
R | 0009890 | biological_process | negative regulation of biosynthetic process |
R | 0016020 | cellular_component | membrane |
R | 0030425 | cellular_component | dendrite |
R | 0031965 | cellular_component | nuclear membrane |
R | 0042470 | cellular_component | melanosome |
R | 0044549 | molecular_function | GTP cyclohydrolase binding |
R | 0045428 | biological_process | regulation of nitric oxide biosynthetic process |
S | 0005515 | molecular_function | protein binding |
S | 0005634 | cellular_component | nucleus |
S | 0005654 | cellular_component | nucleoplasm |
S | 0005737 | cellular_component | cytoplasm |
S | 0005829 | cellular_component | cytosol |
S | 0009890 | biological_process | negative regulation of biosynthetic process |
S | 0016020 | cellular_component | membrane |
S | 0030425 | cellular_component | dendrite |
S | 0031965 | cellular_component | nuclear membrane |
S | 0042470 | cellular_component | melanosome |
S | 0044549 | molecular_function | GTP cyclohydrolase binding |
S | 0045428 | biological_process | regulation of nitric oxide biosynthetic process |
T | 0005515 | molecular_function | protein binding |
T | 0005634 | cellular_component | nucleus |
T | 0005654 | cellular_component | nucleoplasm |
T | 0005737 | cellular_component | cytoplasm |
T | 0005829 | cellular_component | cytosol |
T | 0009890 | biological_process | negative regulation of biosynthetic process |
T | 0016020 | cellular_component | membrane |
T | 0030425 | cellular_component | dendrite |
T | 0031965 | cellular_component | nuclear membrane |
T | 0042470 | cellular_component | melanosome |
T | 0044549 | molecular_function | GTP cyclohydrolase binding |
T | 0045428 | biological_process | regulation of nitric oxide biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 301 |
Chain | Residue |
A | CYS141 |
A | HIS144 |
A | CYS212 |
B | 8GT301 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue PHE L 101 |
Chain | Residue |
C | GLU236 |
L | GLN9 |
L | ILE10 |
L | GLN75 |
M | VAL73 |
site_id | AC3 |
Number of Residues | 17 |
Details | binding site for residue 8GT B 301 |
Chain | Residue |
A | CYS141 |
A | HIS143 |
A | HIS144 |
A | VAL181 |
A | GLN182 |
A | GLU183 |
A | HIS210 |
A | CYS212 |
A | ARG216 |
A | ZN301 |
B | LEU163 |
B | GLY164 |
B | LEU165 |
B | SER166 |
B | LYS167 |
B | ARG170 |
F | ARG97 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue ZN B 302 |
Chain | Residue |
B | CYS141 |
B | HIS144 |
B | CYS212 |
C | 8GT301 |
site_id | AC5 |
Number of Residues | 17 |
Details | binding site for residue 8GT C 301 |
Chain | Residue |
B | CYS141 |
B | HIS143 |
B | HIS144 |
B | VAL181 |
B | GLN182 |
B | GLU183 |
B | HIS210 |
B | CYS212 |
B | ARG216 |
B | ZN302 |
C | LEU163 |
C | GLY164 |
C | LEU165 |
C | SER166 |
C | LYS167 |
C | ARG170 |
J | ARG97 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue ZN C 302 |
Chain | Residue |
C | CYS141 |
C | HIS144 |
C | CYS212 |
D | 8GT302 |
site_id | AC7 |
Number of Residues | 17 |
Details | binding site for residue 8GT E 301 |
Chain | Residue |
A | LEU163 |
A | GLY164 |
A | LEU165 |
A | SER166 |
A | LYS167 |
A | ARG170 |
E | CYS141 |
E | HIS143 |
E | HIS144 |
E | VAL181 |
E | GLN182 |
E | GLU183 |
E | HIS210 |
E | CYS212 |
E | ARG216 |
E | ZN302 |
G | ARG97 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue ZN E 302 |
Chain | Residue |
E | CYS141 |
E | HIS144 |
E | CYS212 |
E | 8GT301 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue ZN G 301 |
Chain | Residue |
G | CYS141 |
G | HIS144 |
G | CYS212 |
H | 8GT301 |
site_id | AD1 |
Number of Residues | 17 |
Details | binding site for residue 8GT H 301 |
Chain | Residue |
E | ARG97 |
G | CYS141 |
G | HIS143 |
G | HIS144 |
G | VAL181 |
G | GLN182 |
G | GLU183 |
G | HIS210 |
G | CYS212 |
G | ARG216 |
G | ZN301 |
H | LEU163 |
H | GLY164 |
H | LEU165 |
H | SER166 |
H | LYS167 |
H | ARG170 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue ZN H 302 |
Chain | Residue |
H | CYS141 |
H | HIS144 |
H | CYS212 |
I | 8GT301 |
site_id | AD3 |
Number of Residues | 17 |
Details | binding site for residue 8GT I 301 |
Chain | Residue |
H | HIS143 |
H | HIS144 |
H | VAL181 |
H | GLN182 |
H | GLU183 |
H | HIS210 |
H | CYS212 |
H | ARG216 |
H | ZN302 |
I | LEU163 |
I | GLY164 |
I | LEU165 |
I | SER166 |
I | LYS167 |
I | ARG170 |
D | ARG97 |
H | CYS141 |
site_id | AD4 |
Number of Residues | 4 |
Details | binding site for residue ZN I 302 |
Chain | Residue |
I | CYS141 |
I | HIS144 |
I | CYS212 |
J | 8GT301 |
site_id | AD5 |
Number of Residues | 17 |
Details | binding site for residue 8GT J 301 |
Chain | Residue |
C | ARG97 |
I | CYS141 |
I | HIS143 |
I | HIS144 |
I | VAL181 |
I | GLN182 |
I | GLU183 |
I | HIS210 |
I | CYS212 |
I | ARG216 |
I | ZN302 |
J | LEU163 |
J | GLY164 |
J | LEU165 |
J | SER166 |
J | LYS167 |
J | ARG170 |
site_id | AD6 |
Number of Residues | 4 |
Details | binding site for residue ZN J 302 |
Chain | Residue |
F | 8GT302 |
J | CYS141 |
J | HIS144 |
J | CYS212 |
site_id | AD7 |
Number of Residues | 17 |
Details | binding site for residue 8GT F 301 |
Chain | Residue |
A | ARG97 |
F | CYS141 |
F | HIS143 |
F | HIS144 |
F | VAL181 |
F | GLN182 |
F | GLU183 |
F | HIS210 |
F | CYS212 |
F | ARG216 |
F | ZN303 |
G | LEU163 |
G | GLY164 |
G | LEU165 |
G | SER166 |
G | LYS167 |
G | ARG170 |
site_id | AD8 |
Number of Residues | 17 |
Details | binding site for residue 8GT F 302 |
Chain | Residue |
B | ARG97 |
F | LEU163 |
F | GLY164 |
F | LEU165 |
F | SER166 |
F | LYS167 |
F | ARG170 |
J | CYS141 |
J | HIS143 |
J | HIS144 |
J | VAL181 |
J | GLN182 |
J | GLU183 |
J | HIS210 |
J | CYS212 |
J | ARG216 |
J | ZN302 |
site_id | AD9 |
Number of Residues | 4 |
Details | binding site for residue ZN F 303 |
Chain | Residue |
F | CYS141 |
F | HIS144 |
F | CYS212 |
F | 8GT301 |
site_id | AE1 |
Number of Residues | 17 |
Details | binding site for residue 8GT D 301 |
Chain | Residue |
D | CYS141 |
D | HIS143 |
D | HIS144 |
D | VAL181 |
D | GLN182 |
D | GLU183 |
D | HIS210 |
D | CYS212 |
D | ARG216 |
D | ZN303 |
E | LEU163 |
E | GLY164 |
E | LEU165 |
E | SER166 |
E | LYS167 |
E | ARG170 |
H | ARG97 |
site_id | AE2 |
Number of Residues | 17 |
Details | binding site for residue 8GT D 302 |
Chain | Residue |
C | CYS141 |
C | HIS143 |
C | HIS144 |
C | VAL181 |
C | GLN182 |
C | GLU183 |
C | HIS210 |
C | CYS212 |
C | ARG216 |
C | ZN302 |
D | LEU163 |
D | GLY164 |
D | LEU165 |
D | SER166 |
D | LYS167 |
D | ARG170 |
I | ARG97 |
site_id | AE3 |
Number of Residues | 4 |
Details | binding site for residue ZN D 303 |
Chain | Residue |
D | CYS141 |
D | HIS144 |
D | CYS212 |
D | 8GT301 |
site_id | AE4 |
Number of Residues | 5 |
Details | binding site for residue PHE K 101 |
Chain | Residue |
B | GLU236 |
K | GLN9 |
K | ILE10 |
K | GLN75 |
L | VAL73 |
site_id | AE5 |
Number of Residues | 5 |
Details | binding site for residue PHE N 101 |
Chain | Residue |
E | GLU236 |
N | GLN9 |
N | ILE10 |
N | GLN75 |
O | VAL73 |
site_id | AE6 |
Number of Residues | 5 |
Details | binding site for residue PHE M 101 |
Chain | Residue |
D | GLU236 |
M | GLN9 |
M | ILE10 |
M | GLN75 |
N | VAL73 |
site_id | AE7 |
Number of Residues | 5 |
Details | binding site for residue PHE O 101 |
Chain | Residue |
A | GLU236 |
K | VAL73 |
O | GLN9 |
O | ILE10 |
O | GLN75 |
site_id | AE8 |
Number of Residues | 5 |
Details | binding site for residue PHE P 101 |
Chain | Residue |
G | GLU236 |
P | GLN9 |
P | ILE10 |
P | GLN75 |
Q | VAL73 |
site_id | AE9 |
Number of Residues | 5 |
Details | binding site for residue PHE Q 101 |
Chain | Residue |
H | GLU236 |
Q | GLN9 |
Q | ILE10 |
Q | GLN75 |
R | VAL73 |
site_id | AF1 |
Number of Residues | 5 |
Details | binding site for residue PHE R 101 |
Chain | Residue |
I | GLU236 |
R | GLN9 |
R | ILE10 |
R | GLN75 |
S | VAL73 |
site_id | AF2 |
Number of Residues | 5 |
Details | binding site for residue PHE S 101 |
Chain | Residue |
J | GLU236 |
S | GLN9 |
S | ILE10 |
S | GLN75 |
T | VAL73 |
site_id | AF3 |
Number of Residues | 5 |
Details | binding site for residue PHE T 101 |
Chain | Residue |
F | GLU236 |
P | VAL73 |
T | GLN9 |
T | ILE10 |
T | GLN75 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 30 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11087827 |
Chain | Residue | Details |
A | CYS141 | |
E | CYS141 | |
E | HIS144 | |
E | CYS212 | |
G | CYS141 | |
G | HIS144 | |
G | CYS212 | |
H | CYS141 | |
H | HIS144 | |
H | CYS212 | |
I | CYS141 | |
A | HIS144 | |
I | HIS144 | |
I | CYS212 | |
J | CYS141 | |
J | HIS144 | |
J | CYS212 | |
F | CYS141 | |
F | HIS144 | |
F | CYS212 | |
D | CYS141 | |
D | HIS144 | |
A | CYS212 | |
D | CYS212 | |
B | CYS141 | |
B | HIS144 | |
B | CYS212 | |
C | CYS141 | |
C | HIS144 | |
C | CYS212 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
Chain | Residue | Details |
A | SER60 | |
D | SER60 | |
B | SER60 | |
C | SER60 | |
E | SER60 | |
G | SER60 | |
H | SER60 | |
I | SER60 | |
J | SER60 | |
F | SER60 |
site_id | SWS_FT_FI3 |
Number of Residues | 10 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:17704208 |
Chain | Residue | Details |
A | SER81 | |
D | SER81 | |
B | SER81 | |
C | SER81 | |
E | SER81 | |
G | SER81 | |
H | SER81 | |
I | SER81 | |
J | SER81 | |
F | SER81 |