6Z6V

Globular head of C1q in complex with the nanobody C1qNb75

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Complement C1q subcomponent subunit A	polymer	136	15230.1	2	UniProt (P02745) Pfam (PF00386)	Homo sapiens (Human)
2	B, E (B, E)	Complement C1q subcomponent subunit B	polymer	141	16156.3	2	UniProt (P02746) Pfam (PF00386)	Homo sapiens (Human)
3	C, F (C, F)	Complement C1q subcomponent subunit C	polymer	139	15176.1	2	UniProt (P02747) Pfam (PF00386)	Homo sapiens (Human)
4	G, H (G, H)	Nanobody C1q75	polymer	131	14392.8	2		Lama glama (Llama)
5	I, J (A, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
6	K, L, M, N, O... (A, B, C, D, E...)	water	water		18.0	332	Chemie (HOH)

Sequence modifications

B, E: 92 - 226 (UniProt: P02746)

PDB	External Database	Details
His 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag
His 231	-	expression tag
His 232	-	expression tag

C, F: 87 - 217 (UniProt: P02747)

PDB	External Database	Details
Gly 84	-	expression tag
Ser 85	-	expression tag
Gly 86	-	expression tag
Gly 218	-	expression tag
Ser 219	-	expression tag
Ala 220	-	expression tag
Lys 221	-	expression tag
Ala 222	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	121910.7
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	122353.1

*Water molecules are not included.