6Z3M

Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) and Neogenin 1 (NEO1).

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, G, H, M...	Growth/differentiation factor 5	polymer	117	13405.5	6	UniProt (P43026) Pfam (PF00019) In PDB	Homo sapiens (Human)	GDF-5,Bone morphogenetic protein 14,BMP-14,Cartilage-derived morphogenetic protein 1,CDMP-1,Lipopolysaccharide-associated protein 4,LPS-associated protein 4,Radotermin
2	C, D, I, J, O...	RGM domain family member B	polymer	371	41036.7	18	UniProt (Q6NW40) Pfam (PF06535) Pfam (PF06534) In PDB	Homo sapiens (Human)	DRG11-responsive axonal guidance and outgrowth of neurite,DRAGON
3	E, F, K, L, Q...	Neogenin	polymer	253	28031.6	6	UniProt (P97798) Pfam (PF00041) In PDB	Mus musculus (House mouse)
4	D, E, F, I, K...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	9	Chemie (NAG)

Sequence modifications

A, B, G, H, M, N: 387 - 501 (UniProt: P43026)

PDB	External Database	Details
Met 385	-	initiating methionine
Lys 386	-	expression tag

C, D, I, J, O, P, c, d, i, j, o, p, S, T, U, V, W, X: 53 - 412 (UniProt: Q6NW40)

PDB	External Database	Details
Glu 50	-	expression tag
Thr 51	-	expression tag
Gly 52	-	expression tag
Gly 225	Glu 225	conflict
Thr 413	-	expression tag
Lys 414	-	expression tag
His 415	-	expression tag
His 416	-	expression tag
His 417	-	expression tag
His 418	-	expression tag
His 419	-	expression tag
His 420	-	expression tag

E, F, K, L, Q, R: 883 - 1123 (UniProt: P97798)

PDB	External Database	Details
Glu 880	-	expression tag
Thr 881	-	expression tag
Gly 882	-	expression tag
Gly 1124	-	expression tag
Thr 1125	-	expression tag
Lys 1126	-	expression tag
His 1127	-	expression tag
His 1128	-	expression tag
His 1129	-	expression tag
His 1130	-	expression tag
His 1131	-	expression tag
His 1132	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	30
	Total formula weight	987283.6
Non-Polymers*	Number of molecules	9
	Total formula weight	1990.9
All*	Total formula weight	989274.5

*Water molecules are not included.