6Z3M
Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) and Neogenin 1 (NEO1).
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, G, H, M... (A, B, G, H, M...) | Growth/differentiation factor 5 | polymer | 117 | 13405.5 | 6 | UniProt (P43026) Pfam (PF00019) | Homo sapiens (Human) | GDF-5,Bone morphogenetic protein 14,BMP-14,Cartilage-derived morphogenetic protein 1,CDMP-1,Lipopolysaccharide-associated protein 4,LPS-associated protein 4,Radotermin |
| 2 | AA, BA, C, CA, D... (C, D, I, J, O...) | RGM domain family member B | polymer | 371 | 41036.7 | 18 | UniProt (Q6NW40) Pfam (PF06535) Pfam (PF06534) | Homo sapiens (Human) | DRG11-responsive axonal guidance and outgrowth of neurite,DRAGON |
| 3 | E, F, K, L, Q... (E, F, K, L, Q...) | Neogenin | polymer | 253 | 28031.6 | 6 | UniProt (P97798) Pfam (PF00041) | Mus musculus (House mouse) | |
| 4 | EA, FA, GA, HA, IA... (D, E, F, I, K...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) |
Sequence modifications
A, B, G, H, M, N: 387 - 501 (UniProt: P43026)
C, D, I, J, O, P, c, d, i, j, o, p, S, T, U, V, W, X: 53 - 412 (UniProt: Q6NW40)
E, F, K, L, Q, R: 883 - 1123 (UniProt: P97798)
| PDB | External Database | Details |
|---|---|---|
| Met 385 | - | initiating methionine |
| Lys 386 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 50 | - | expression tag |
| Thr 51 | - | expression tag |
| Gly 52 | - | expression tag |
| Gly 225 | Glu 225 | conflict |
| Thr 413 | - | expression tag |
| Lys 414 | - | expression tag |
| His 415 | - | expression tag |
| His 416 | - | expression tag |
| His 417 | - | expression tag |
| His 418 | - | expression tag |
| His 419 | - | expression tag |
| His 420 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 880 | - | expression tag |
| Thr 881 | - | expression tag |
| Gly 882 | - | expression tag |
| Gly 1124 | - | expression tag |
| Thr 1125 | - | expression tag |
| Lys 1126 | - | expression tag |
| His 1127 | - | expression tag |
| His 1128 | - | expression tag |
| His 1129 | - | expression tag |
| His 1130 | - | expression tag |
| His 1131 | - | expression tag |
| His 1132 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 30 |
| Total formula weight | 987283.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1990.9 | |
| All* | Total formula weight | 989274.5 |
