6Z3M

Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) and Neogenin 1 (NEO1).

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008083	molecular_function	growth factor activity
B	0005576	cellular_component	extracellular region
B	0008083	molecular_function	growth factor activity
C	0005515	molecular_function	protein binding
C	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
C	0005886	cellular_component	plasma membrane
C	0007155	biological_process	cell adhesion
C	0007165	biological_process	signal transduction
C	0010604	biological_process	positive regulation of macromolecule metabolic process
C	0015026	molecular_function	coreceptor activity
C	0030509	biological_process	BMP signaling pathway
C	0042802	molecular_function	identical protein binding
C	0045121	cellular_component	membrane raft
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0080090	biological_process	regulation of primary metabolic process
C	0098552	cellular_component	side of membrane
D	0005515	molecular_function	protein binding
D	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
D	0005886	cellular_component	plasma membrane
D	0007155	biological_process	cell adhesion
D	0007165	biological_process	signal transduction
D	0010604	biological_process	positive regulation of macromolecule metabolic process
D	0015026	molecular_function	coreceptor activity
D	0030509	biological_process	BMP signaling pathway
D	0042802	molecular_function	identical protein binding
D	0045121	cellular_component	membrane raft
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0080090	biological_process	regulation of primary metabolic process
D	0098552	cellular_component	side of membrane
G	0005576	cellular_component	extracellular region
G	0008083	molecular_function	growth factor activity
H	0005576	cellular_component	extracellular region
H	0008083	molecular_function	growth factor activity
I	0005515	molecular_function	protein binding
I	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
I	0005886	cellular_component	plasma membrane
I	0007155	biological_process	cell adhesion
I	0007165	biological_process	signal transduction
I	0010604	biological_process	positive regulation of macromolecule metabolic process
I	0015026	molecular_function	coreceptor activity
I	0030509	biological_process	BMP signaling pathway
I	0042802	molecular_function	identical protein binding
I	0045121	cellular_component	membrane raft
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0080090	biological_process	regulation of primary metabolic process
I	0098552	cellular_component	side of membrane
J	0005515	molecular_function	protein binding
J	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
J	0005886	cellular_component	plasma membrane
J	0007155	biological_process	cell adhesion
J	0007165	biological_process	signal transduction
J	0010604	biological_process	positive regulation of macromolecule metabolic process
J	0015026	molecular_function	coreceptor activity
J	0030509	biological_process	BMP signaling pathway
J	0042802	molecular_function	identical protein binding
J	0045121	cellular_component	membrane raft
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0080090	biological_process	regulation of primary metabolic process
J	0098552	cellular_component	side of membrane
M	0005576	cellular_component	extracellular region
M	0008083	molecular_function	growth factor activity
N	0005576	cellular_component	extracellular region
N	0008083	molecular_function	growth factor activity
O	0005515	molecular_function	protein binding
O	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
O	0005886	cellular_component	plasma membrane
O	0007155	biological_process	cell adhesion
O	0007165	biological_process	signal transduction
O	0010604	biological_process	positive regulation of macromolecule metabolic process
O	0015026	molecular_function	coreceptor activity
O	0030509	biological_process	BMP signaling pathway
O	0042802	molecular_function	identical protein binding
O	0045121	cellular_component	membrane raft
O	0045893	biological_process	positive regulation of DNA-templated transcription
O	0080090	biological_process	regulation of primary metabolic process
O	0098552	cellular_component	side of membrane
P	0005515	molecular_function	protein binding
P	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
P	0005886	cellular_component	plasma membrane
P	0007155	biological_process	cell adhesion
P	0007165	biological_process	signal transduction
P	0010604	biological_process	positive regulation of macromolecule metabolic process
P	0015026	molecular_function	coreceptor activity
P	0030509	biological_process	BMP signaling pathway
P	0042802	molecular_function	identical protein binding
P	0045121	cellular_component	membrane raft
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0080090	biological_process	regulation of primary metabolic process
P	0098552	cellular_component	side of membrane
S	0005515	molecular_function	protein binding
S	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
S	0005886	cellular_component	plasma membrane
S	0007155	biological_process	cell adhesion
S	0007165	biological_process	signal transduction
S	0010604	biological_process	positive regulation of macromolecule metabolic process
S	0015026	molecular_function	coreceptor activity
S	0030509	biological_process	BMP signaling pathway
S	0042802	molecular_function	identical protein binding
S	0045121	cellular_component	membrane raft
S	0045893	biological_process	positive regulation of DNA-templated transcription
S	0080090	biological_process	regulation of primary metabolic process
S	0098552	cellular_component	side of membrane
T	0005515	molecular_function	protein binding
T	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
T	0005886	cellular_component	plasma membrane
T	0007155	biological_process	cell adhesion
T	0007165	biological_process	signal transduction
T	0010604	biological_process	positive regulation of macromolecule metabolic process
T	0015026	molecular_function	coreceptor activity
T	0030509	biological_process	BMP signaling pathway
T	0042802	molecular_function	identical protein binding
T	0045121	cellular_component	membrane raft
T	0045893	biological_process	positive regulation of DNA-templated transcription
T	0080090	biological_process	regulation of primary metabolic process
T	0098552	cellular_component	side of membrane
U	0005515	molecular_function	protein binding
U	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
U	0005886	cellular_component	plasma membrane
U	0007155	biological_process	cell adhesion
U	0007165	biological_process	signal transduction
U	0010604	biological_process	positive regulation of macromolecule metabolic process
U	0015026	molecular_function	coreceptor activity
U	0030509	biological_process	BMP signaling pathway
U	0042802	molecular_function	identical protein binding
U	0045121	cellular_component	membrane raft
U	0045893	biological_process	positive regulation of DNA-templated transcription
U	0080090	biological_process	regulation of primary metabolic process
U	0098552	cellular_component	side of membrane
V	0005515	molecular_function	protein binding
V	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
V	0005886	cellular_component	plasma membrane
V	0007155	biological_process	cell adhesion
V	0007165	biological_process	signal transduction
V	0010604	biological_process	positive regulation of macromolecule metabolic process
V	0015026	molecular_function	coreceptor activity
V	0030509	biological_process	BMP signaling pathway
V	0042802	molecular_function	identical protein binding
V	0045121	cellular_component	membrane raft
V	0045893	biological_process	positive regulation of DNA-templated transcription
V	0080090	biological_process	regulation of primary metabolic process
V	0098552	cellular_component	side of membrane
W	0005515	molecular_function	protein binding
W	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
W	0005886	cellular_component	plasma membrane
W	0007155	biological_process	cell adhesion
W	0007165	biological_process	signal transduction
W	0010604	biological_process	positive regulation of macromolecule metabolic process
W	0015026	molecular_function	coreceptor activity
W	0030509	biological_process	BMP signaling pathway
W	0042802	molecular_function	identical protein binding
W	0045121	cellular_component	membrane raft
W	0045893	biological_process	positive regulation of DNA-templated transcription
W	0080090	biological_process	regulation of primary metabolic process
W	0098552	cellular_component	side of membrane
X	0005515	molecular_function	protein binding
X	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
X	0005886	cellular_component	plasma membrane
X	0007155	biological_process	cell adhesion
X	0007165	biological_process	signal transduction
X	0010604	biological_process	positive regulation of macromolecule metabolic process
X	0015026	molecular_function	coreceptor activity
X	0030509	biological_process	BMP signaling pathway
X	0042802	molecular_function	identical protein binding
X	0045121	cellular_component	membrane raft
X	0045893	biological_process	positive regulation of DNA-templated transcription
X	0080090	biological_process	regulation of primary metabolic process
X	0098552	cellular_component	side of membrane
c	0005515	molecular_function	protein binding
c	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
c	0005886	cellular_component	plasma membrane
c	0007155	biological_process	cell adhesion
c	0007165	biological_process	signal transduction
c	0010604	biological_process	positive regulation of macromolecule metabolic process
c	0015026	molecular_function	coreceptor activity
c	0030509	biological_process	BMP signaling pathway
c	0042802	molecular_function	identical protein binding
c	0045121	cellular_component	membrane raft
c	0045893	biological_process	positive regulation of DNA-templated transcription
c	0080090	biological_process	regulation of primary metabolic process
c	0098552	cellular_component	side of membrane
d	0005515	molecular_function	protein binding
d	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
d	0005886	cellular_component	plasma membrane
d	0007155	biological_process	cell adhesion
d	0007165	biological_process	signal transduction
d	0010604	biological_process	positive regulation of macromolecule metabolic process
d	0015026	molecular_function	coreceptor activity
d	0030509	biological_process	BMP signaling pathway
d	0042802	molecular_function	identical protein binding
d	0045121	cellular_component	membrane raft
d	0045893	biological_process	positive regulation of DNA-templated transcription
d	0080090	biological_process	regulation of primary metabolic process
d	0098552	cellular_component	side of membrane
i	0005515	molecular_function	protein binding
i	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
i	0005886	cellular_component	plasma membrane
i	0007155	biological_process	cell adhesion
i	0007165	biological_process	signal transduction
i	0010604	biological_process	positive regulation of macromolecule metabolic process
i	0015026	molecular_function	coreceptor activity
i	0030509	biological_process	BMP signaling pathway
i	0042802	molecular_function	identical protein binding
i	0045121	cellular_component	membrane raft
i	0045893	biological_process	positive regulation of DNA-templated transcription
i	0080090	biological_process	regulation of primary metabolic process
i	0098552	cellular_component	side of membrane
j	0005515	molecular_function	protein binding
j	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
j	0005886	cellular_component	plasma membrane
j	0007155	biological_process	cell adhesion
j	0007165	biological_process	signal transduction
j	0010604	biological_process	positive regulation of macromolecule metabolic process
j	0015026	molecular_function	coreceptor activity
j	0030509	biological_process	BMP signaling pathway
j	0042802	molecular_function	identical protein binding
j	0045121	cellular_component	membrane raft
j	0045893	biological_process	positive regulation of DNA-templated transcription
j	0080090	biological_process	regulation of primary metabolic process
j	0098552	cellular_component	side of membrane
o	0005515	molecular_function	protein binding
o	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
o	0005886	cellular_component	plasma membrane
o	0007155	biological_process	cell adhesion
o	0007165	biological_process	signal transduction
o	0010604	biological_process	positive regulation of macromolecule metabolic process
o	0015026	molecular_function	coreceptor activity
o	0030509	biological_process	BMP signaling pathway
o	0042802	molecular_function	identical protein binding
o	0045121	cellular_component	membrane raft
o	0045893	biological_process	positive regulation of DNA-templated transcription
o	0080090	biological_process	regulation of primary metabolic process
o	0098552	cellular_component	side of membrane
p	0005515	molecular_function	protein binding
p	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
p	0005886	cellular_component	plasma membrane
p	0007155	biological_process	cell adhesion
p	0007165	biological_process	signal transduction
p	0010604	biological_process	positive regulation of macromolecule metabolic process
p	0015026	molecular_function	coreceptor activity
p	0030509	biological_process	BMP signaling pathway
p	0042802	molecular_function	identical protein binding
p	0045121	cellular_component	membrane raft
p	0045893	biological_process	positive regulation of DNA-templated transcription
p	0080090	biological_process	regulation of primary metabolic process
p	0098552	cellular_component	side of membrane

Functional Information from PROSITE/UniProt

site_id	PS00250
Number of Residues	16
Details	TGF_BETA_1 TGF-beta family signature. IiaPleYeafhCeGlC

Chain	Residue	Details
A	ILE418-CYS433

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	594
Details	Domain: {"description":"Fibronectin type-III 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	485
Details	Domain: {"description":"Fibronectin type-III 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---