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6Z3M

Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) and Neogenin 1 (NEO1).

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0008083molecular_functiongrowth factor activity
B0005576cellular_componentextracellular region
B0008083molecular_functiongrowth factor activity
C0005515molecular_functionprotein binding
C0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
C0005886cellular_componentplasma membrane
C0007155biological_processcell adhesion
C0007165biological_processsignal transduction
C0010604biological_processpositive regulation of macromolecule metabolic process
C0015026molecular_functioncoreceptor activity
C0030509biological_processBMP signaling pathway
C0042802molecular_functionidentical protein binding
C0045121cellular_componentmembrane raft
C0045893biological_processpositive regulation of DNA-templated transcription
C0080090biological_processregulation of primary metabolic process
C0098552cellular_componentside of membrane
D0005515molecular_functionprotein binding
D0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
D0005886cellular_componentplasma membrane
D0007155biological_processcell adhesion
D0007165biological_processsignal transduction
D0010604biological_processpositive regulation of macromolecule metabolic process
D0015026molecular_functioncoreceptor activity
D0030509biological_processBMP signaling pathway
D0042802molecular_functionidentical protein binding
D0045121cellular_componentmembrane raft
D0045893biological_processpositive regulation of DNA-templated transcription
D0080090biological_processregulation of primary metabolic process
D0098552cellular_componentside of membrane
G0005576cellular_componentextracellular region
G0008083molecular_functiongrowth factor activity
H0005576cellular_componentextracellular region
H0008083molecular_functiongrowth factor activity
I0005515molecular_functionprotein binding
I0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
I0005886cellular_componentplasma membrane
I0007155biological_processcell adhesion
I0007165biological_processsignal transduction
I0010604biological_processpositive regulation of macromolecule metabolic process
I0015026molecular_functioncoreceptor activity
I0030509biological_processBMP signaling pathway
I0042802molecular_functionidentical protein binding
I0045121cellular_componentmembrane raft
I0045893biological_processpositive regulation of DNA-templated transcription
I0080090biological_processregulation of primary metabolic process
I0098552cellular_componentside of membrane
J0005515molecular_functionprotein binding
J0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
J0005886cellular_componentplasma membrane
J0007155biological_processcell adhesion
J0007165biological_processsignal transduction
J0010604biological_processpositive regulation of macromolecule metabolic process
J0015026molecular_functioncoreceptor activity
J0030509biological_processBMP signaling pathway
J0042802molecular_functionidentical protein binding
J0045121cellular_componentmembrane raft
J0045893biological_processpositive regulation of DNA-templated transcription
J0080090biological_processregulation of primary metabolic process
J0098552cellular_componentside of membrane
M0005576cellular_componentextracellular region
M0008083molecular_functiongrowth factor activity
N0005576cellular_componentextracellular region
N0008083molecular_functiongrowth factor activity
O0005515molecular_functionprotein binding
O0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
O0005886cellular_componentplasma membrane
O0007155biological_processcell adhesion
O0007165biological_processsignal transduction
O0010604biological_processpositive regulation of macromolecule metabolic process
O0015026molecular_functioncoreceptor activity
O0030509biological_processBMP signaling pathway
O0042802molecular_functionidentical protein binding
O0045121cellular_componentmembrane raft
O0045893biological_processpositive regulation of DNA-templated transcription
O0080090biological_processregulation of primary metabolic process
O0098552cellular_componentside of membrane
P0005515molecular_functionprotein binding
P0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
P0005886cellular_componentplasma membrane
P0007155biological_processcell adhesion
P0007165biological_processsignal transduction
P0010604biological_processpositive regulation of macromolecule metabolic process
P0015026molecular_functioncoreceptor activity
P0030509biological_processBMP signaling pathway
P0042802molecular_functionidentical protein binding
P0045121cellular_componentmembrane raft
P0045893biological_processpositive regulation of DNA-templated transcription
P0080090biological_processregulation of primary metabolic process
P0098552cellular_componentside of membrane
S0005515molecular_functionprotein binding
S0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
S0005886cellular_componentplasma membrane
S0007155biological_processcell adhesion
S0007165biological_processsignal transduction
S0010604biological_processpositive regulation of macromolecule metabolic process
S0015026molecular_functioncoreceptor activity
S0030509biological_processBMP signaling pathway
S0042802molecular_functionidentical protein binding
S0045121cellular_componentmembrane raft
S0045893biological_processpositive regulation of DNA-templated transcription
S0080090biological_processregulation of primary metabolic process
S0098552cellular_componentside of membrane
T0005515molecular_functionprotein binding
T0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
T0005886cellular_componentplasma membrane
T0007155biological_processcell adhesion
T0007165biological_processsignal transduction
T0010604biological_processpositive regulation of macromolecule metabolic process
T0015026molecular_functioncoreceptor activity
T0030509biological_processBMP signaling pathway
T0042802molecular_functionidentical protein binding
T0045121cellular_componentmembrane raft
T0045893biological_processpositive regulation of DNA-templated transcription
T0080090biological_processregulation of primary metabolic process
T0098552cellular_componentside of membrane
U0005515molecular_functionprotein binding
U0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
U0005886cellular_componentplasma membrane
U0007155biological_processcell adhesion
U0007165biological_processsignal transduction
U0010604biological_processpositive regulation of macromolecule metabolic process
U0015026molecular_functioncoreceptor activity
U0030509biological_processBMP signaling pathway
U0042802molecular_functionidentical protein binding
U0045121cellular_componentmembrane raft
U0045893biological_processpositive regulation of DNA-templated transcription
U0080090biological_processregulation of primary metabolic process
U0098552cellular_componentside of membrane
V0005515molecular_functionprotein binding
V0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
V0005886cellular_componentplasma membrane
V0007155biological_processcell adhesion
V0007165biological_processsignal transduction
V0010604biological_processpositive regulation of macromolecule metabolic process
V0015026molecular_functioncoreceptor activity
V0030509biological_processBMP signaling pathway
V0042802molecular_functionidentical protein binding
V0045121cellular_componentmembrane raft
V0045893biological_processpositive regulation of DNA-templated transcription
V0080090biological_processregulation of primary metabolic process
V0098552cellular_componentside of membrane
W0005515molecular_functionprotein binding
W0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
W0005886cellular_componentplasma membrane
W0007155biological_processcell adhesion
W0007165biological_processsignal transduction
W0010604biological_processpositive regulation of macromolecule metabolic process
W0015026molecular_functioncoreceptor activity
W0030509biological_processBMP signaling pathway
W0042802molecular_functionidentical protein binding
W0045121cellular_componentmembrane raft
W0045893biological_processpositive regulation of DNA-templated transcription
W0080090biological_processregulation of primary metabolic process
W0098552cellular_componentside of membrane
X0005515molecular_functionprotein binding
X0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
X0005886cellular_componentplasma membrane
X0007155biological_processcell adhesion
X0007165biological_processsignal transduction
X0010604biological_processpositive regulation of macromolecule metabolic process
X0015026molecular_functioncoreceptor activity
X0030509biological_processBMP signaling pathway
X0042802molecular_functionidentical protein binding
X0045121cellular_componentmembrane raft
X0045893biological_processpositive regulation of DNA-templated transcription
X0080090biological_processregulation of primary metabolic process
X0098552cellular_componentside of membrane
c0005515molecular_functionprotein binding
c0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
c0005886cellular_componentplasma membrane
c0007155biological_processcell adhesion
c0007165biological_processsignal transduction
c0010604biological_processpositive regulation of macromolecule metabolic process
c0015026molecular_functioncoreceptor activity
c0030509biological_processBMP signaling pathway
c0042802molecular_functionidentical protein binding
c0045121cellular_componentmembrane raft
c0045893biological_processpositive regulation of DNA-templated transcription
c0080090biological_processregulation of primary metabolic process
c0098552cellular_componentside of membrane
d0005515molecular_functionprotein binding
d0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
d0005886cellular_componentplasma membrane
d0007155biological_processcell adhesion
d0007165biological_processsignal transduction
d0010604biological_processpositive regulation of macromolecule metabolic process
d0015026molecular_functioncoreceptor activity
d0030509biological_processBMP signaling pathway
d0042802molecular_functionidentical protein binding
d0045121cellular_componentmembrane raft
d0045893biological_processpositive regulation of DNA-templated transcription
d0080090biological_processregulation of primary metabolic process
d0098552cellular_componentside of membrane
i0005515molecular_functionprotein binding
i0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
i0005886cellular_componentplasma membrane
i0007155biological_processcell adhesion
i0007165biological_processsignal transduction
i0010604biological_processpositive regulation of macromolecule metabolic process
i0015026molecular_functioncoreceptor activity
i0030509biological_processBMP signaling pathway
i0042802molecular_functionidentical protein binding
i0045121cellular_componentmembrane raft
i0045893biological_processpositive regulation of DNA-templated transcription
i0080090biological_processregulation of primary metabolic process
i0098552cellular_componentside of membrane
j0005515molecular_functionprotein binding
j0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
j0005886cellular_componentplasma membrane
j0007155biological_processcell adhesion
j0007165biological_processsignal transduction
j0010604biological_processpositive regulation of macromolecule metabolic process
j0015026molecular_functioncoreceptor activity
j0030509biological_processBMP signaling pathway
j0042802molecular_functionidentical protein binding
j0045121cellular_componentmembrane raft
j0045893biological_processpositive regulation of DNA-templated transcription
j0080090biological_processregulation of primary metabolic process
j0098552cellular_componentside of membrane
o0005515molecular_functionprotein binding
o0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
o0005886cellular_componentplasma membrane
o0007155biological_processcell adhesion
o0007165biological_processsignal transduction
o0010604biological_processpositive regulation of macromolecule metabolic process
o0015026molecular_functioncoreceptor activity
o0030509biological_processBMP signaling pathway
o0042802molecular_functionidentical protein binding
o0045121cellular_componentmembrane raft
o0045893biological_processpositive regulation of DNA-templated transcription
o0080090biological_processregulation of primary metabolic process
o0098552cellular_componentside of membrane
p0005515molecular_functionprotein binding
p0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
p0005886cellular_componentplasma membrane
p0007155biological_processcell adhesion
p0007165biological_processsignal transduction
p0010604biological_processpositive regulation of macromolecule metabolic process
p0015026molecular_functioncoreceptor activity
p0030509biological_processBMP signaling pathway
p0042802molecular_functionidentical protein binding
p0045121cellular_componentmembrane raft
p0045893biological_processpositive regulation of DNA-templated transcription
p0080090biological_processregulation of primary metabolic process
p0098552cellular_componentside of membrane
Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IiaPleYeafhCeGlC
ChainResidueDetails
AILE418-CYS433

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues594
DetailsDomain: {"description":"Fibronectin type-III 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues485
DetailsDomain: {"description":"Fibronectin type-III 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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