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6Z3J

Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) (crystal form 1)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Growth/differentiation factor 5polymer11713358.42UniProt (P43026)
Pfam (PF00019)
Homo sapiens (Human)GDF-5,Bone morphogenetic protein 14,BMP-14,Cartilage-derived morphogenetic protein 1,CDMP-1,Lipopolysaccharide-associated protein 4,LPS-associated protein 4,Radotermin
2C, D
(C, D)
RGM domain family member Bpolymer9610532.72UniProt (Q6NW40)
Pfam (PF06535)
Homo sapiens (Human)DRG11-responsive axonal guidance and outgrowth of neurite,DRAGON
3E, J
(A, C)
SULFATE IONnon-polymer96.12Chemie (SO4)
4F, H
(A, B)
GLYCEROLnon-polymer92.12Chemie (GOL)
5G, K, N
(B, C, D)
1,2-ETHANEDIOLnon-polymer62.13Chemie (EDO)
6I, L, O
(B, C, D)
CHLORIDE IONnon-polymer35.53Chemie (CL)
7M
(D)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.21Chemie (NAG)
8P, Q, R, S
(A, B, C, D)
waterwater18.0142Chemie (HOH)
Sequence modifications
A, B: 387 - 501 (UniProt: P43026)
PDBExternal DatabaseDetails
Met 385-initiating methionine
Lys 386-expression tag
Lys 487Tyr 487engineered mutation
Asp 489Gln 489engineered mutation
C, D: 53 - 136 (UniProt: Q6NW40)
PDBExternal DatabaseDetails
Glu 50-expression tag
Thr 51-expression tag
Gly 52-expression tag
Gly 137-expression tag
Thr 138-expression tag
Lys 139-expression tag
His 140-expression tag
His 141-expression tag
His 142-expression tag
His 143-expression tag
His 144-expression tag
His 145-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight47782.3
Non-Polymers*Number of molecules11
Total formula weight890.1
All*Total formula weight48672.4
*Water molecules are not included.

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PDB entries from 2025-07-09

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