6Z3H

Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) (crystal form 2)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Growth/differentiation factor 5	polymer	117	13405.5	1	UniProt (P43026) Pfam (PF00019) In PDB	Homo sapiens (Human)	GDF-5,Bone morphogenetic protein 14,BMP-14,Cartilage-derived morphogenetic protein 1,CDMP-1,Lipopolysaccharide-associated protein 4,LPS-associated protein 4,Radotermin
2	B	RGM domain family member B	polymer	96	10532.7	1	UniProt (Q6NW40) Pfam (PF06535) In PDB	Homo sapiens (Human)	DRG11-responsive axonal guidance and outgrowth of neurite,DRAGON

Sequence modifications

A: 387 - 501 (UniProt: P43026)

PDB	External Database	Details
Met 385	-	initiating methionine
Lys 386	-	expression tag

B: 53 - 136 (UniProt: Q6NW40)

PDB	External Database	Details
Glu 50	-	expression tag
Thr 51	-	expression tag
Gly 52	-	expression tag
Gly 137	-	expression tag
Thr 138	-	expression tag
Lys 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	23938.2
All*	Total formula weight	23938.2

*Water molecules are not included.