6Z32

Human cation-independent mannose 6-phosphate/IGF2 receptor domains 7-11

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cation-independent mannose-6-phosphate receptor	polymer	737	80832.9	2	UniProt (P11717) Pfam (PF00878)	Homo sapiens (Human)	M6PR,300 kDa mannose 6-phosphate receptor,MPR 300,Insulin-like growth factor 2 receptor,Insulin-like growth factor II receptor,IGF-II receptor,M6P/IGF2 receptor,M6P/IGF2R
2	C, D (C, D)	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	2	In PDB GlyTouCan (G01760ZU)
3	E (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	F, G, H (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)

Sequence modifications

A, B: 927 - 1649 (UniProt: P11717)

PDB	External Database	Details
Glu 913	-	expression tag
Thr 914	-	expression tag
Gly 915	-	expression tag
Gln 916	-	expression tag
Leu 917	-	expression tag
Lys 918	-	expression tag
His 919	-	expression tag
His 920	-	expression tag
His 921	-	expression tag
His 922	-	expression tag
His 923	-	expression tag
His 924	-	expression tag
Glu 925	-	expression tag
Phe 926	-	expression tag
Gly 1619	Arg 1619	variant

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	161665.9
Branched	Number of molecules	2
	Total formula weight	2145.9
Non-Polymers*	Number of molecules	4
	Total formula weight	759.7
All*	Total formula weight	164571.5

*Water molecules are not included.