6Z2C
Engineered lipocalin C3A5 in complex with a transition state analog
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Neutrophil gelatinase-associated lipocalin | polymer | 188 | 21819.8 | 3 | UniProt (P80188) Pfam (PF00061) In PDB | Homo sapiens (Human) | NGAL,25 kDa alpha-2-microglobulin-related subunit of MMP-9,Lipocalin-2,Oncogene 24p3,Siderocalin,p25 |
2 | A, B, C | 1,7,8,9,10,10-hexachloro-4-carboxypentyl-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione | non-polymer | 484.0 | 3 | Chemie (Q5E) | |||
3 | water | water | 18.0 | 272 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 178 (UniProt: P80188)
PDB | External Database | Details |
---|---|---|
His 28 | Gln 48 | engineered mutation |
Met 36 | Leu 56 | engineered mutation |
Gly 40 | Ala 60 | engineered mutation |
Asp 41 | Ile 61 | engineered mutation |
Tyr 49 | Gln 69 | engineered mutation |
Arg 52 | Tyr 72 | engineered mutation |
Trp 68 | Ser 88 | engineered mutation |
Trp 70 | Leu 90 | engineered mutation |
Leu 72 | Arg 92 | engineered mutation |
Pro 73 | Lys 93 | engineered mutation |
Lys 77 | Asp 97 | engineered mutation |
Phe 79 | Trp 99 | engineered mutation |
Asn 81 | Arg 101 | engineered mutation |
Ser 87 | Cys 107 | engineered mutation |
Leu 96 | Asn 116 | engineered mutation |
Gln 103 | Leu 123 | engineered mutation |
Leu 106 | Tyr 126 | engineered mutation |
Thr 125 | Lys 145 | engineered mutation |
Ile 127 | Ser 147 | engineered mutation |
Arg 132 | Tyr 152 | engineered mutation |
Tyr 134 | Lys 154 | engineered mutation |
Ser 179 | - | expression tag |
Ala 180 | - | expression tag |
Trp 181 | - | expression tag |
Ser 182 | - | expression tag |
His 183 | - | expression tag |
Pro 184 | - | expression tag |
Gln 185 | - | expression tag |
Phe 186 | - | expression tag |
Glu 187 | - | expression tag |
Lys 188 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 65459.5 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1452.0 | |
All* | Total formula weight | 66911.5 |