6Z1N

Structure of the human heterotetrameric cis-prenyltransferase complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	polymer	340	39202.0	1	UniProt (Q86SQ9) Pfam (PF01255)	Homo sapiens (Human)	Cis-isoprenyltransferase,Cis-IPTase,Cis-prenyltransferase subunit hCIT,Epididymis tissue protein Li 189m
2	B (B)	Dehydrodolichyl diphosphate synthase complex subunit NUS1	polymer	219	24211.6	1	UniProt (Q96E22) Pfam (PF01255)	Homo sapiens (Human)	Cis-prenyltransferase subunit NgBR,Nogo-B receptor,NgBR,Nuclear undecaprenyl pyrophosphate synthase 1 homolog
3	C (A)	FARNESYL DIPHOSPHATE	non-polymer		382.3	1	Chemie (FPP)
4	D (A)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
5	E (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	F, G (A, B)	water	water		18.0	122	Chemie (HOH)

Sequence modifications

A: 1 - 333 (UniProt: Q86SQ9)

PDB	External Database	Details
Gly -6	-	expression tag
Ser -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag

B: 73 - 293 (UniProt: Q96E22)

PDB	External Database	Details
Gly 66	-	expression tag
Ser 67	-	expression tag
Gly 68	-	expression tag
Ser 69	-	expression tag
Gly 70	-	expression tag
Ser 71	-	expression tag
Gly 72	-	expression tag
-	Tyr 167	deletion
-	Ser 168	deletion
-	Pro 169	deletion
-	Glu 170	deletion
-	Phe 171	deletion
-	Ala 172	deletion
-	Asn 173	deletion
-	Ser 174	deletion
-	Asn 175	deletion

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	63413.6
Non-Polymers*	Number of molecules	3
	Total formula weight	501.6
All*	Total formula weight	63915.2

*Water molecules are not included.