6Z1N
Structure of the human heterotetrameric cis-prenyltransferase complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002094 | molecular_function | polyprenyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006486 | biological_process | protein glycosylation |
| A | 0006489 | biological_process | dolichyl diphosphate biosynthetic process |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016094 | biological_process | polyprenol biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0045547 | molecular_function | dehydrodolichyl diphosphate synthase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1904423 | cellular_component | dehydrodolichyl diphosphate synthase complex |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0019408 | biological_process | dolichol biosynthetic process |
| B | 1904423 | cellular_component | dehydrodolichyl diphosphate synthase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue FPP A 401 |
| Chain | Residue |
| A | TRP3 |
| A | PHE55 |
| A | ALA77 |
| A | ARG85 |
| A | VAL152 |
| A | MG403 |
| A | HOH507 |
| A | HOH547 |
| A | MET33 |
| A | ASP34 |
| A | GLY35 |
| A | ASN36 |
| A | ARG37 |
| A | ARG38 |
| A | HIS51 |
| A | GLY54 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 A 402 |
| Chain | Residue |
| A | ARG205 |
| A | ARG211 |
| A | SER213 |
| A | HOH512 |
| A | HOH534 |
| A | HOH538 |
| A | HOH553 |
| A | HOH555 |
| B | LEU291 |
| B | GLY292 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 403 |
| Chain | Residue |
| A | ASP34 |
| A | FPP401 |
| A | HOH507 |
| A | HOH547 |
| A | HOH555 |
Functional Information from PROSITE/UniProt
| site_id | PS01066 |
| Number of Residues | 18 |
| Details | UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DILIRTSGevRlSdFLLW |
| Chain | Residue | Details |
| A | ASP201-TRP218 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000303|PubMed:21572394 |
| Chain | Residue | Details |
| B | ILE117-TYR135 | |
| A | ARG38 | |
| A | ARG85 | |
| A | ARG205 | |
| A | ARG211 | |
| A | SER213 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:32817466 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21572394 |
| Chain | Residue | Details |
| B | ASN144 | |
| B | ALA280 |
