6Z1N

Structure of the human heterotetrameric cis-prenyltransferase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004659	molecular_function	prenyltransferase activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006486	biological_process	obsolete protein glycosylation
A	0006489	biological_process	dolichyl diphosphate biosynthetic process
A	0006629	biological_process	lipid metabolic process
A	0016094	biological_process	polyprenol biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0043048	biological_process	dolichyl monophosphate biosynthetic process
A	0045547	molecular_function	ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity
A	0046872	molecular_function	metal ion binding
A	1904423	cellular_component	dehydrodolichyl diphosphate synthase complex
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0043048	biological_process	dolichyl monophosphate biosynthetic process
B	1904423	cellular_component	dehydrodolichyl diphosphate synthase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue FPP A 401

Chain	Residue
A	TRP3
A	PHE55
A	ALA77
A	ARG85
A	VAL152
A	MG403
A	HOH507
A	HOH547
A	MET33
A	ASP34
A	GLY35
A	ASN36
A	ARG37
A	ARG38
A	HIS51
A	GLY54

---

site_id	AC2
Number of Residues	10
Details	binding site for residue PO4 A 402

Chain	Residue
A	ARG205
A	ARG211
A	SER213
A	HOH512
A	HOH534
A	HOH538
A	HOH553
A	HOH555
B	LEU291
B	GLY292

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 403

Chain	Residue
A	ASP34
A	FPP401
A	HOH507
A	HOH547
A	HOH555

---

Functional Information from PROSITE/UniProt

site_id	PS01066
Number of Residues	18
Details	UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DILIRTSGevRlSdFLLW

Chain	Residue	Details
A	ASP201-TRP218

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32817466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33077723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35584224","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6Z1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PB1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35584224","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7PAX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32817466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35584224","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7PAX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"21572394","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Motif: {"description":"RXG motif; crucial for prenyltransferase activity","evidences":[{"source":"PubMed","id":"32817466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28842490","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32817466","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21572394","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---