6Z0Y

HtrA1 inactive protease domain S328A with CARASIL mutations D174R R274Q

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Serine protease HTRA1	polymer	236	25659.4	3	UniProt (Q92743) Pfam (PF13365)	Homo sapiens (Human)	High-temperature requirement A serine peptidase 1,L56,Serine protease 11
2	D, E, F, G (A, B)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3	H, I, J (A, B, C)	water	water		18.0	8	Chemie (HOH)

Sequence modifications

A, B, C: 161 - 375 (UniProt: Q92743)

PDB	External Database	Details
Met 140	-	initiating methionine
Gly 141	-	expression tag
Ser 142	-	expression tag
Ser 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag
His 148	-	expression tag
His 149	-	expression tag
Ser 150	-	expression tag
Ser 151	-	expression tag
Gly 152	-	expression tag
Leu 153	-	expression tag
Val 154	-	expression tag
Pro 155	-	expression tag
Arg 156	-	expression tag
Gly 157	-	expression tag
Ser 158	-	expression tag
His 159	-	expression tag
Met 160	-	expression tag
Arg 174	Asp 174	engineered mutation
Gln 274	Arg 274	engineered mutation
Ala 328	Ser 328	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	76978.1
Non-Polymers*	Number of molecules	4
	Total formula weight	384.3
All*	Total formula weight	77362.3

*Water molecules are not included.