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6YZ4

Crystal structure of MKK7 (MAP2K7) with ibrutinib bound at allosteric site

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ADual specificity mitogen-activated protein kinase kinase 7polymer30734944.61UniProt (O14733)
Pfam (PF00069)
In PDB
Homo sapiens (Human)MAPKK 7,JNK-activating kinase 2,MAPK/ERK kinase 7,MEK 7,Stress-activated protein kinase kinase 4,SAPKK4,c-Jun N-terminal kinase kinase 2,JNKK 2
2A1,2-ETHANEDIOLnon-polymer62.19Chemie (EDO)
3ADIMETHYL SULFOXIDEnon-polymer78.14Chemie (DMS)
4A1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-onenon-polymer440.51Chemie (1E8)
5waterwater18.0310Chemie (HOH)
Sequence modifications
A: 116 - 421 (UniProt: O14733)
PDBExternal DatabaseDetails
Ser 115-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight34944.6
Non-Polymers*Number of molecules14
Total formula weight1311.6
All*Total formula weight36256.3
*Water molecules are not included.

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PDB entries from 2024-06-12

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