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6YZ1

The crystal structure of SARS-CoV-2 nsp10-nsp16 methyltransferase complex with Sinefungin

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
nsp16polymer29933486.41UniProt (P0DTD1)
Pfam (PF06460)
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)pp1ab,ORF1ab polyprotein,nsp16
2B
(B)
nsp10polymer12313126.11UniProt (P0DTD1)
Pfam (PF09401)
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)pp1ab,ORF1ab polyprotein,nsp10
3C
(A)
SINEFUNGINnon-polymer381.41Chemie (SFG)
4D
(A)
2-(N-MORPHOLINO)-ETHANESULFONIC ACIDnon-polymer195.21Chemie (MES)
5E, F
(B)
ZINC IONnon-polymer65.42Chemie (ZN)
6G, H
(A, B)
waterwater18.0261Chemie (HOH)
Sequence modifications
A: 1 - 298 (UniProt: P0DTD1)
PDBExternal DatabaseDetails
Met 0-initiating methionine
B: 10 - 131 (UniProt: P0DTD1)
PDBExternal DatabaseDetails
Met 9-initiating methionine
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight46612.5
Non-Polymers*Number of molecules4
Total formula weight707.4
All*Total formula weight47320.0
*Water molecules are not included.

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PDB entries from 2025-08-06

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