6YYA
Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphoribosylaminoimidazole-succinocarboxamide synthase | polymer | 306 | 33900.2 | 1 | UniProt (B1MHW4) Pfam (PF01259) | Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) | SAICAR synthetase |
| 2 | B (A) | 4-azanyl-6-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]pyrimidine-5-carbonitrile | non-polymer | 294.3 | 1 | Chemie (PZK) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, F, G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | H (A) | water | water | 18.0 | 250 | Chemie (HOH) |
Sequence modifications
A: 1 - 297 (UniProt: B1MHW4)
| PDB | External Database | Details |
|---|---|---|
| Met -8 | - | initiating methionine |
| Ser -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33900.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 672.6 | |
| All* | Total formula weight | 34572.8 |
