6YW1
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 2OG and RaPID-derived silent allosteric cyclic peptide 3C (14-mer)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Egl nine homolog 1 | polymer | 233 | 26036.6 | 1 | UniProt (Q9GZT9) Pfam (PF13640) In PDB | Homo sapiens (Human) | Hypoxia-inducible factor prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20 |
| 2 | B | PHD2-SPECIFIC RaPID CYCLIC PEPTIDE 3C (14-MER) | polymer | 14 | 1801.0 | 1 | synthetic construct | ||
| 3 | A | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 4 | A | 2-OXOGLUTARIC ACID | non-polymer | 146.1 | 1 | Chemie (AKG) | |||
| 5 | A | BICARBONATE ION | non-polymer | 61.0 | 1 | Chemie (BCT) | |||
| 6 | water | water | 18.0 | 244 | Chemie (HOH) |
Sequence modifications
A: 181 - 407 (UniProt: Q9GZT9)
| PDB | External Database | Details |
|---|---|---|
| Gly 175 | - | expression tag |
| Ser 176 | - | expression tag |
| His 177 | - | expression tag |
| Met 178 | - | expression tag |
| Ala 179 | - | expression tag |
| Ser 180 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27837.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 262.1 | |
| All* | Total formula weight | 28099.7 |
