6YVH

CWC22-CWC27-EIF4A3 Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, D, E (A, B, D, F)	Pre-mRNA-splicing factor CWC22 homolog	polymer	291	33493.0	4	UniProt (Q9HCG8) Pfam (PF02854)	Homo sapiens (Human)	Nucampholin homolog,fSAPb
2	C, J, K, L (C, I, E, G)	Spliceosome-associated protein CWC27 homolog	polymer	57	6560.1	4	UniProt (Q6UX04)	Homo sapiens (Human)	Antigen NY-CO-10,Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog,PPIase CWC27,Serologically defined colon cancer antigen 10
3	F, G, H, I (H, J, K, L)	Eukaryotic initiation factor 4A-III	polymer	166	19441.2	4	UniProt (P38919) Pfam (PF00271)	Homo sapiens (Human)	eIF4A-III,ATP-dependent RNA helicase DDX48,ATP-dependent RNA helicase eIF4A-3,DEAD box protein 48,Eukaryotic initiation factor 4A-like NUK-34,Eukaryotic translation initiation factor 4A isoform 3,Nuclear matrix protein 265,hNMP 265

Sequence modifications

A, B, D, F: 119 - 406 (UniProt: Q9HCG8)

PDB	External Database	Details
Arg 116	-	expression tag
Ser 117	-	expression tag
Met 118	-	expression tag

C, I, E, G: 378 - 431 (UniProt: Q6UX04)

PDB	External Database	Details
Arg 375	-	expression tag
Ser 376	-	expression tag
Met 377	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	237977.4
All*	Total formula weight	237977.4

*Water molecules are not included.