6YT7

GLYCOSYLATED KNOB/DUMMY-HOLE FC FRAGMENT

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Immunoglobulin gamma-1 heavy chain	polymer	240	27086.5	1	UniProt (P0DOX5) Pfam (PF07654)	Homo sapiens (Human)	Immunoglobulin gamma-1 heavy chain NIE
2	B (B)	Ig gamma-1 chain C region	polymer	227	25400.8	1	UniProt (P01857) Pfam (PF07654)	Homo sapiens (Human)
3	C, D (C, D)	beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1422.3	2	In PDB GlyTouCan (G61334IA)
4	E, F (A, B)	water	water		18.0	205	Chemie (HOH)

Sequence modifications

A: 221 - 447 (UniProt: P0DOX5)

PDB	External Database	Details
Trp 366	Thr 368	engineered mutation
Glu 370	Lys 372	engineered mutation
Gly 448	-	expression tag
Gly 449	-	expression tag
Gly 450	-	expression tag
Gly 451	-	expression tag
Ser 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag

B: 221 - 447 (UniProt: P01857)

PDB	External Database	Details
Cys 349	Tyr 232	engineered mutation
Ser 366	Thr 249	engineered mutation
Ala 368	Leu 251	engineered mutation
Val 407	Tyr 290	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	52487.2
Branched	Number of molecules	2
	Total formula weight	2844.6
All*	Total formula weight	55331.8

*Water molecules are not included.