6YSN
Human TRPC5 in complex with Pico145 (HC-608)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Maltose/maltodextrin-binding periplasmic protein,Short transient receptor potential channel 5 | polymer | 1146 | 130760.0 | 4 | UniProt (P0AEX9) UniProt (Q9UL62) Pfam (PF01547) Pfam (PF12796) Pfam (PF00023) Pfam (PF08344) Pfam (PF00520) | Escherichia coli (strain K12) | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,TrpC5,Transient receptor protein 5,hTRP5 |
| 2 | E, F, G, H (A, B, C, D) | 7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)-8-[3-(trifluoromethyloxy)phenoxy]purine-2,6-dione | non-polymer | 524.9 | 4 | Chemie (PJQ) |
Sequence modifications
A, B, C, D: -379 - -11 (UniProt: P0AEX9)
A, B, C, D: 1 - 765 (UniProt: Q9UL62)
| PDB | External Database | Details |
|---|---|---|
| Met -380 | - | initiating methionine |
| Leu -26 | - | insertion |
| Glu -25 | - | insertion |
| Val -24 | - | insertion |
| Ser -10 | - | linker |
| Ser -9 | - | linker |
| Gly -8 | - | linker |
| Leu -7 | - | linker |
| Gly -6 | - | linker |
| Val -5 | - | linker |
| Leu -4 | - | linker |
| Phe -3 | - | linker |
| Gln -2 | - | linker |
| Gly -1 | - | linker |
| Pro 0 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Met 455 | Val 455 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 523040.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2099.5 | |
| All* | Total formula weight | 525139.6 |
