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6YSN

Human TRPC5 in complex with Pico145 (HC-608)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0006811biological_processmonoatomic ion transport
A0006974biological_processDNA damage response
A0008643biological_processcarbohydrate transport
A0015144molecular_functioncarbohydrate transmembrane transporter activity
A0015768biological_processmaltose transport
A0016020cellular_componentmembrane
A0030288cellular_componentouter membrane-bounded periplasmic space
A0034219biological_processcarbohydrate transmembrane transport
A0034289biological_processdetection of maltose stimulus
A0042597cellular_componentperiplasmic space
A0042956biological_processmaltodextrin transmembrane transport
A0043190cellular_componentATP-binding cassette (ABC) transporter complex
A0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A0055085biological_processtransmembrane transport
A0060326biological_processcell chemotaxis
A0070588biological_processcalcium ion transmembrane transport
A1901982molecular_functionmaltose binding
A1990060cellular_componentmaltose transport complex
B0005216molecular_functionmonoatomic ion channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0006811biological_processmonoatomic ion transport
B0006974biological_processDNA damage response
B0008643biological_processcarbohydrate transport
B0015144molecular_functioncarbohydrate transmembrane transporter activity
B0015768biological_processmaltose transport
B0016020cellular_componentmembrane
B0030288cellular_componentouter membrane-bounded periplasmic space
B0034219biological_processcarbohydrate transmembrane transport
B0034289biological_processdetection of maltose stimulus
B0042597cellular_componentperiplasmic space
B0042956biological_processmaltodextrin transmembrane transport
B0043190cellular_componentATP-binding cassette (ABC) transporter complex
B0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
B0055085biological_processtransmembrane transport
B0060326biological_processcell chemotaxis
B0070588biological_processcalcium ion transmembrane transport
B1901982molecular_functionmaltose binding
B1990060cellular_componentmaltose transport complex
C0005216molecular_functionmonoatomic ion channel activity
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0006811biological_processmonoatomic ion transport
C0006974biological_processDNA damage response
C0008643biological_processcarbohydrate transport
C0015144molecular_functioncarbohydrate transmembrane transporter activity
C0015768biological_processmaltose transport
C0016020cellular_componentmembrane
C0030288cellular_componentouter membrane-bounded periplasmic space
C0034219biological_processcarbohydrate transmembrane transport
C0034289biological_processdetection of maltose stimulus
C0042597cellular_componentperiplasmic space
C0042956biological_processmaltodextrin transmembrane transport
C0043190cellular_componentATP-binding cassette (ABC) transporter complex
C0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C0055085biological_processtransmembrane transport
C0060326biological_processcell chemotaxis
C0070588biological_processcalcium ion transmembrane transport
C1901982molecular_functionmaltose binding
C1990060cellular_componentmaltose transport complex
D0005216molecular_functionmonoatomic ion channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0006811biological_processmonoatomic ion transport
D0006974biological_processDNA damage response
D0008643biological_processcarbohydrate transport
D0015144molecular_functioncarbohydrate transmembrane transporter activity
D0015768biological_processmaltose transport
D0016020cellular_componentmembrane
D0030288cellular_componentouter membrane-bounded periplasmic space
D0034219biological_processcarbohydrate transmembrane transport
D0034289biological_processdetection of maltose stimulus
D0042597cellular_componentperiplasmic space
D0042956biological_processmaltodextrin transmembrane transport
D0043190cellular_componentATP-binding cassette (ABC) transporter complex
D0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
D0055085biological_processtransmembrane transport
D0060326biological_processcell chemotaxis
D0070588biological_processcalcium ion transmembrane transport
D1901982molecular_functionmaltose binding
D1990060cellular_componentmaltose transport complex
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue PJQ A 901
ChainResidue
ATYR524
ACYS525
AGLN573
APHE576
DALA602
DTHR603
DGLY606
DTHR607

site_idAC2
Number of Residues8
Detailsbinding site for residue PJQ B 901
ChainResidue
ATHR603
AGLY606
ATHR607
BTYR524
BCYS525
BGLN573
BPHE576
AALA602

site_idAC3
Number of Residues8
Detailsbinding site for residue PJQ C 901
ChainResidue
BALA602
BTHR603
BGLY606
BTHR607
CTYR524
CCYS525
CGLN573
CPHE576

site_idAC4
Number of Residues8
Detailsbinding site for residue PJQ D 801
ChainResidue
CALA602
CTHR603
CGLY606
CTHR607
DTYR524
DCYS525
DGLN573
DPHE576

Functional Information from PROSITE/UniProt
site_idPS00962
Number of Residues12
DetailsRIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. LiSLFTANSHLG
ChainResidueDetails
ALEU493-GLY504

site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
APRO-273-ASN-256

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1464
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-LYS330
DMET1-LYS330
DLYS420-LEU437
DARG492-ARG512
ALYS420-LEU437
AARG492-ARG512
BMET1-LYS330
BLYS420-LEU437
BARG492-ARG512
CMET1-LYS330
CLYS420-LEU437
CARG492-ARG512

site_idSWS_FT_FI2
Number of Residues480
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU331-SER351
BMET471-LEU491
BMET513-ASN533
BMET604-MET624
CLEU331-SER351
CPRO399-ILE419
CMET438-VAL458
CMET471-LEU491
CMET513-ASN533
CMET604-MET624
DLEU331-SER351
APRO399-ILE419
DPRO399-ILE419
DMET438-VAL458
DMET471-LEU491
DMET513-ASN533
DMET604-MET624
AMET438-VAL458
AMET471-LEU491
AMET513-ASN533
AMET604-MET624
BLEU331-SER351
BPRO399-ILE419
BMET438-VAL458

site_idSWS_FT_FI3
Number of Residues504
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
APRO352-PRO398
DPRO352-PRO398
DLYS459-GLU470
DGLY534-THR603
ALYS459-GLU470
AGLY534-THR603
BPRO352-PRO398
BLYS459-GLU470
BGLY534-THR603
CPRO352-PRO398
CLYS459-GLU470
CGLY534-THR603

site_idSWS_FT_FI4
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN461
BASN461
CASN461
DASN461

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PDB entries from 2024-07-24

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