6YN1
Crystal structure of histone chaperone APLF acidic domain bound to the histone H2A-H2B-H3-H4 octamer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, EA, F, JA, K... (A, F, K, P, U...) | Histone H2A | polymer | 107 | 11754.8 | 8 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) | Xenopus laevis (African clawed frog) | |
| 2 | AA, B, FA, G, KA... (B, G, L, Q, V...) | Histone H2B | polymer | 100 | 11311.2 | 8 | UniProt (A0A1L8FQA5) Pfam (PF00125) UniProt (by SIFTS) (P02281) | Xenopus laevis (African clawed frog) | |
| 3 | BA, C, GA, H, LA... (C, H, M, R, W...) | Histone H3 | polymer | 99 | 11633.6 | 8 | UniProt (A0A310TTQ1) Pfam (PF00125) UniProt (by SIFTS) (P02302) | Xenopus laevis (African clawed frog) | |
| 4 | CA, D, HA, I, MA... (D, I, N, S, X...) | Histone H4 | polymer | 84 | 9540.3 | 8 | UniProt (P62799) Pfam (PF15511) | Xenopus laevis (African clawed frog) | |
| 5 | DA, E, IA, J, NA... (E, J, O, T, Y...) | Aprataxin and PNK-like factor | polymer | 43 | 4995.8 | 8 | UniProt (Q8IW19) | Homo sapiens (Human) | Apurinic-apyrimidinic endonuclease APLF,PNK and APTX-like FHA domain-containing protein,XRCC1-interacting protein 1 |
| 6 | AB, BB, CB, OA, PA... (h, j, A, D, H...) | GLYCEROL | non-polymer | 92.1 | 14 | Chemie (GOL) | |||
| 7 | RA (J) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | AC, BC, CC, DB, DC... (Y, Z, a, A, b...) | water | water | 18.0 | 415 | Chemie (HOH) |
Sequence modifications
A, F, K, P, U, Z, e, j: 13 - 118 (UniProt: Q6AZJ8)
B, G, L, Q, V, a, f, k: 27 - 125 (UniProt: A0A1L8FQA5)
C, H, M, R, W, b, g, l: 38 - 135 (UniProt: A0A310TTQ1)
D, I, N, S, X, c, h, m: 20 - 102 (UniProt: P62799)
E, J, O, T, Y, d, i, n: 449 - 490 (UniProt: Q8IW19)
| PDB | External Database | Details |
|---|---|---|
| Met 12 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 26 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 37 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 19 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 40 |
| Total formula weight | 393885.0 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1324.8 | |
| All* | Total formula weight | 395209.8 |
