6YKY
Biochemical, Cellular and Structural Characterization of Novel ERK3 Inhibitors
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Mitogen-activated protein kinase 6 | polymer | 319 | 36193.7 | 4 | UniProt (Q16659) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAPK 6,Extracellular signal-regulated kinase 3,ERK-3,MAP kinase isoform p97,p97-MAPK |
2 | A, B, C, D | 3-(4-methoxyphenyl)-~{N}-[(3~{R})-1-pyridin-4-ylpyrrolidin-3-yl]-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine | non-polymer | 388.4 | 4 | Chemie (OWQ) | |||
3 | water | water | 18.0 | 189 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 9 - 327 (UniProt: Q16659)
PDB | External Database | Details |
---|---|---|
Val 290 | Leu 290 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 144774.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1553.7 | |
All* | Total formula weight | 146328.4 |