6YIK
Crystal structure of the CREBBP bromodomain in complex with a tetrahydroquinoxaline ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | CREBBP | polymer | 119 | 14223.3 | 3 | UniProt (Q92793) Pfam (PF00439) | Homo sapiens (Human) | |
| 2 | D, E, F, G, H (A, B, C) | (3~{R})-~{N}-[3-(3,4-dihydro-2~{H}-quinolin-1-yl)-2,2-bis(fluoranyl)propyl]-3-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-quinoxaline-5-carboxamide | non-polymer | 414.4 | 5 | Chemie (OSQ) | |||
| 3 | I, J, K (A, B, C) | water | water | 18.0 | 385 | Chemie (HOH) |
Sequence modifications
A, B, C: 1081 - 1197 (UniProt: Q92793)
| PDB | External Database | Details |
|---|---|---|
| Ser 1079 | - | expression tag |
| Met 1080 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 42670.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 2072.2 | |
| All* | Total formula weight | 44742.3 |
