6YIJ

Crystal structure of the CREBBP bromodomain in complex with a benzo-diazepine ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	CREBBP	polymer	119	14223.3	7	UniProt (Q92793) Pfam (PF00439)	Homo sapiens (Human)
2	H, I, J, K, L... (A, B, C, D, E...)	(4~{R})-6-[(~{E})-5-(7-methoxy-3,4-dihydro-2~{H}-quinolin-1-yl)pent-1-enyl]-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one	non-polymer		405.5	7	Chemie (OSN)
3	O, P, Q, R, S... (A, B, C, D, E...)	water	water		18.0	224	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G: 1081 - 1197 (UniProt: Q92793)

PDB	External Database	Details
Ser 1079	-	expression tag
Met 1080	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	99563.4
Non-Polymers*	Number of molecules	7
	Total formula weight	2838.7
All*	Total formula weight	102402.2

*Water molecules are not included.