6YIJ
Crystal structure of the CREBBP bromodomain in complex with a benzo-diazepine ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004402 | molecular_function | histone acetyltransferase activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0004402 | molecular_function | histone acetyltransferase activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0004402 | molecular_function | histone acetyltransferase activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0004402 | molecular_function | histone acetyltransferase activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0004402 | molecular_function | histone acetyltransferase activity |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0004402 | molecular_function | histone acetyltransferase activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0004402 | molecular_function | histone acetyltransferase activity |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue OSN A 1201 |
| Chain | Residue |
| A | LEU1109 |
| A | PRO1110 |
| A | LEU1120 |
| A | TYR1125 |
| A | ASN1168 |
| A | HOH1303 |
| D | ARG1173 |
| D | OSN1201 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue OSN B 1201 |
| Chain | Residue |
| B | PRO1110 |
| B | VAL1115 |
| B | LEU1120 |
| B | ASN1168 |
| B | VAL1174 |
| B | HOH1306 |
| G | ARG1173 |
| G | VAL1174 |
| G | OSN1201 |
| B | LEU1109 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue OSN C 1201 |
| Chain | Residue |
| C | LEU1109 |
| C | PRO1110 |
| C | VAL1115 |
| C | ASN1168 |
| C | VAL1174 |
| C | HOH1305 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue OSN D 1201 |
| Chain | Residue |
| A | ARG1173 |
| A | OSN1201 |
| D | PRO1110 |
| D | LEU1120 |
| D | ASN1168 |
| D | VAL1174 |
| D | HOH1301 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue OSN E 1201 |
| Chain | Residue |
| E | PRO1110 |
| E | VAL1115 |
| E | LEU1120 |
| E | TYR1125 |
| E | ASN1168 |
| E | HOH1302 |
| F | ARG1173 |
| F | OSN1201 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue OSN F 1201 |
| Chain | Residue |
| E | ARG1173 |
| E | VAL1174 |
| E | OSN1201 |
| F | PRO1110 |
| F | LEU1120 |
| F | TYR1125 |
| F | TYR1167 |
| F | ASN1168 |
| F | HOH1302 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue OSN G 1201 |
| Chain | Residue |
| B | ARG1173 |
| B | OSN1201 |
| G | PRO1110 |
| G | TYR1125 |
| G | ASN1168 |
| G | HOH1307 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY |
| Chain | Residue | Details |
| A | SER1108-TYR1167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 749 |
| Details | Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 322 |
| Details | Region: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"24361270","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 126 |
| Details | Region: {"description":"Interaction with ASF1A","evidences":[{"source":"PubMed","id":"24616510","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
