6YG6
Crystal structure of MKK7 (MAP2K7) covalently bound with type-II inhibitor TL10-105
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Dual specificity mitogen-activated protein kinase kinase 7 | polymer | 307 | 34986.6 | 2 | UniProt (O14733) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAPKK 7,JNK-activating kinase 2,MAPK/ERK kinase 7,MEK 7,Stress-activated protein kinase kinase 4,SAPKK4,c-Jun N-terminal kinase kinase 2,JNKK 2 |
| 2 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 3 | A, B | ~{N}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{S})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide | non-polymer | 639.7 | 2 | Chemie (OQ8) | |||
| 4 | water | water | 18.0 | 163 | Chemie (HOH) |
Sequence modifications
A, B: 116 - 421 (UniProt: O14733)
| PDB | External Database | Details |
|---|---|---|
| Ser 115 | - | expression tag |
| Asp 287 | Ser 271 | engineered mutation |
| Asp 291 | Thr 275 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69973.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1527.7 | |
| All* | Total formula weight | 71500.9 |
