6Y9B
Cryo-EM structure of trimeric human STEAP1 bound to three Fab120.545 fragments
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, H, I (C, A, B) | Metalloreductase STEAP1 | polymer | 380 | 44183.7 | 3 | UniProt (Q9UHE8) Pfam (PF01794) | Homo sapiens (Human) | Six-transmembrane epithelial antigen of prostate 1 |
| 2 | B, F, G (L, M, N) | Fab120.545 light chain | polymer | 220 | 24344.1 | 3 | Mus musculus (house mouse) | ||
| 3 | C, D, E (H, I, J) | Fab120.545 heavy chain | polymer | 238 | 26149.9 | 3 | Mus musculus (house mouse) | ||
| 4 | J, L, N (C, A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 3 | Chemie (HEM) | |||
| 5 | K, M, O (C, A, B) | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE | non-polymer | 591.8 | 3 | Chemie (XP4) |
Sequence modifications
C, A, B: 2 - 339 (UniProt: Q9UHE8)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Ala 340 | - | expression tag |
| Ala 341 | - | expression tag |
| Ala 342 | - | expression tag |
| Gly 343 | - | expression tag |
| Ala 344 | - | expression tag |
| Ala 345 | - | expression tag |
| Trp 346 | - | expression tag |
| Ser 347 | - | expression tag |
| His 348 | - | expression tag |
| Pro 349 | - | expression tag |
| Gln 350 | - | expression tag |
| Phe 351 | - | expression tag |
| Glu 352 | - | expression tag |
| Lys 353 | - | expression tag |
| Gly 354 | - | expression tag |
| Ala 355 | - | expression tag |
| Ala 356 | - | expression tag |
| Trp 357 | - | expression tag |
| Ser 358 | - | expression tag |
| His 359 | - | expression tag |
| Pro 360 | - | expression tag |
| Gln 361 | - | expression tag |
| Phe 362 | - | expression tag |
| Glu 363 | - | expression tag |
| Lys 364 | - | expression tag |
| Gly 365 | - | expression tag |
| Ala 366 | - | expression tag |
| Ala 367 | - | expression tag |
| Trp 368 | - | expression tag |
| Ser 369 | - | expression tag |
| His 370 | - | expression tag |
| Pro 371 | - | expression tag |
| Gln 372 | - | expression tag |
| Phe 373 | - | expression tag |
| Glu 374 | - | expression tag |
| Lys 375 | - | expression tag |
| Gly 376 | - | expression tag |
| Ala 377 | - | expression tag |
| Ala 378 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 284033.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3624.8 | |
| All* | Total formula weight | 287657.9 |
