6Y79
Cryo-EM structure of a respiratory complex I F89A mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Subunit NUAM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 728 | 79088.1 | 1 | UniProt (Q9UUU3) Pfam (PF13510) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) UniProt (by SIFTS) (F2Z6F1) | Yarrowia lipolytica (Candida lipolytica) | |
| 2 | B (B) | Subunit NUBM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 488 | 53829.5 | 1 | UniProt (Q9UUU2) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) UniProt (by SIFTS) (F2Z660) | Yarrowia lipolytica (Candida lipolytica) | |
| 3 | C (C) | Subunit NUCM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 466 | 52494.9 | 1 | UniProt (Q9UUU1) Pfam (PF00346) UniProt (by SIFTS) (F2Z626) | Yarrowia lipolytica (Candida lipolytica) | |
| 4 | D (D) | Subunit NIMM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 87 | 9806.2 | 1 | UniProt (A0A1D8NC63) Pfam (PF15879) UniProt (by SIFTS) (B5FVD3) | Yarrowia lipolytica (Candida lipolytica) | |
| 5 | E (E) | Subunit NUEM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 375 | 42765.7 | 1 | UniProt (A0A371BY45) Pfam (PF01370) UniProt (by SIFTS) (Q6C7X4) | Yarrowia lipolytica | |
| 6 | F (F) | Subunit NUFM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 144 | 16657.9 | 1 | UniProt (A0A371C5F3) Pfam (PF04716) UniProt (by SIFTS) (Q6C4W9) | Yarrowia lipolytica | |
| 7 | G (G) | Subunit NUGM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 281 | 32389.6 | 1 | UniProt (Q9UUU0) Pfam (PF00329) UniProt (by SIFTS) (F2Z6D7) | Yarrowia lipolytica (Candida lipolytica) | |
| 8 | H (H) | Subunit NUHM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 243 | 27247.4 | 1 | UniProt (Q9UUT9) Pfam (PF01257) UniProt (by SIFTS) (F2Z6C0) | Yarrowia lipolytica (Candida lipolytica) | |
| 9 | I (I) | Subunit NUIM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 229 | 25682.3 | 1 | UniProt (Q9UUT8) Pfam (PF12838) UniProt (by SIFTS) (F2Z619) | Yarrowia lipolytica (Candida lipolytica) | |
| 10 | J (J) | Subunit NUJM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 198 | 20849.6 | 1 | UniProt (A0A371CB65) UniProt (by SIFTS) (Q6C674) | Yarrowia lipolytica | |
| 11 | K (K) | Subunit NUKM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 210 | 23455.2 | 1 | UniProt (Q9UUT7) | Yarrowia lipolytica (Candida lipolytica) | |
| 12 | L (L) | Subunit NULM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 89 | 9815.9 | 1 | UniProt (Q9B6D4) Pfam (PF00420) | Yarrowia lipolytica | NADH dehydrogenase subunit 4L, subunit ND4L |
| 13 | M (M) | Subunit NUMM of protein NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 136 | 15149.0 | 1 | UniProt (A0A1H6Q8Z5) Pfam (PF10276) UniProt (by SIFTS) (Q6C8J9) | Yarrowia lipolytica (Candida lipolytica) | |
| 14 | N (O) | Acyl carrier protein ACPM1 of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 109 | 12053.6 | 1 | UniProt (A0A1H6PXT9) Pfam (PF00550) UniProt (by SIFTS) (Q6C926) | Yarrowia lipolytica (Candida lipolytica) | |
| 15 | O (P) | Subunit NB4M of protein NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 124 | 14702.7 | 1 | UniProt (A0A1D8N3C8) Pfam (PF13233) UniProt (by SIFTS) (Q6CI60) | Yarrowia lipolytica | Subunit NB4M of protein NADH:Ubiquinone Oxidoreductase (Complex I) |
| 16 | P (Q) | Acyl carrier protein ACPM2 of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 132 | 14444.5 | 1 | UniProt (A0A1D8NG21) Pfam (PF00550) UniProt (by SIFTS) (Q6C7X2) | Yarrowia lipolytica (Candida lipolytica) | |
| 17 | Q (R) | Subunit NI2M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 109 | 12902.9 | 1 | UniProt (A0A1D8NDL1) UniProt (by SIFTS) (Q6C9Z1) | Yarrowia lipolytica (Candida lipolytica) | |
| 18 | R (S) | Subunit NESM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 249 | 28479.9 | 1 | UniProt (Q6ZY23) UniProt (by SIFTS) (F2Z673) | Yarrowia lipolytica | |
| 19 | S (U) | Subunit NUPM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 172 | 19355.2 | 1 | UniProt (A0A371C2D0) Pfam (PF06747) UniProt (by SIFTS) (Q6CGB4) | Yarrowia lipolytica | |
| 20 | T (W) | Subunit NB6M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 123 | 14112.4 | 1 | UniProt (A0A1H6PPE5) Pfam (PF06212) UniProt (by SIFTS) (B5FVF8) | Yarrowia lipolytica (Candida lipolytica) | |
| 21 | U (X) | Subunit NUXM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 169 | 18588.2 | 1 | UniProt (A0A1D8NKB4) Pfam (PF10785) Pfam (PF12853) UniProt (by SIFTS) (Q6C4A6) | Yarrowia lipolytica (Candida lipolytica) | |
| 22 | V (Y) | Subunit NUYM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 161 | 18656.1 | 1 | UniProt (A0A1D8N7X0) Pfam (PF04800) UniProt (by SIFTS) (Q6CEK9) | Yarrowia lipolytica (Candida lipolytica) | |
| 23 | W (Z) | Subunit NUZM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 182 | 19772.5 | 1 | UniProt (A0A1D8N3H5) UniProt (by SIFTS) (Q6CI10) | Yarrowia lipolytica | |
| 24 | X (a) | Subunit NIAM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 149 | 17328.5 | 1 | UniProt (A0A1D8ND94) Pfam (PF05821) UniProt (by SIFTS) (Q6CA88) | Yarrowia lipolytica | |
| 25 | Y (b) | Subunit NEBM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 74 | 8059.4 | 1 | UniProt (A0A1D8NGI5) | Yarrowia lipolytica | |
| 26 | Z (c) | Subunit NB2M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 60 | 6948.9 | 1 | UniProt (A0A371C0F2) Pfam (PF08122) UniProt (by SIFTS) (B5FVE5) | Yarrowia lipolytica | |
| 27 | AA (d) | Subunit NIDM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 92 | 11039.3 | 1 | UniProt (A0A1D8N596) Pfam (PF10249) UniProt (by SIFTS) (B5RSK3) | Yarrowia lipolytica (Candida lipolytica) | |
| 28 | BA (e) | Subunit NUVM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 67 | 7807.1 | 1 | UniProt (A0A1D8NFX6) | Yarrowia lipolytica | |
| 29 | CA (f) | Subunit NI8M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 87 | 9621.1 | 1 | UniProt (A0A1H6PJS3) Pfam (PF05047) UniProt (by SIFTS) (Q6CD73) | Yarrowia lipolytica (Candida lipolytica) | |
| 30 | DA (g) | Subunit NI9M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 78 | 8921.2 | 1 | UniProt (A0A1D8NJR0) UniProt (by SIFTS) (B5FVF3) | Yarrowia lipolytica | |
| 31 | EA (h) | Subunit N7BM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 138 | 16175.1 | 1 | UniProt (A0A1D8N5V2) Pfam (PF05071) UniProt (by SIFTS) (Q6CG53) | Yarrowia lipolytica | |
| 32 | FA (i) | Subunit NUUM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 90 | 9794.0 | 1 | UniProt (A0A1H6Q311) | Yarrowia lipolytica | |
| 33 | GA (j) | Subunit NB5M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 93 | 10494.9 | 1 | UniProt (Q6ZY24) UniProt (by SIFTS) (B5RSK9) | Yarrowia lipolytica (Candida lipolytica) | |
| 34 | HA (n) | Subunit NUNM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 120 | 13523.1 | 1 | UniProt (A0A371CFV9) UniProt (by SIFTS) (Q6C1R9) | Yarrowia lipolytica | |
| 35 | IA (1) | Subunit NU1M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 341 | 38361.3 | 1 | UniProt (S5U3V2) Pfam (PF00146) UniProt (by SIFTS) (Q9B6E8) | Yarrowia lipolytica | |
| 36 | JA (2) | Subunit NU2M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 469 | 53353.4 | 1 | UniProt (S5U4R9) Pfam (PF00361) UniProt (by SIFTS) (Q9B6C8) | Yarrowia lipolytica | |
| 37 | KA (3) | Subunit NU3M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 128 | 14478.3 | 1 | UniProt (S5TMS4) Pfam (PF00507) UniProt (by SIFTS) (Q9B6C7) | Yarrowia lipolytica | |
| 38 | LA (4) | Subunit NU4M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 486 | 54506.6 | 1 | UniProt (S5TMP9) Pfam (PF00361) UniProt (by SIFTS) (Q9B6D6) | Yarrowia lipolytica | |
| 39 | MA (5) | Subunit NU5M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 655 | 73740.7 | 1 | UniProt (S5TF58) Pfam (PF00662) Pfam (PF00361) UniProt (by SIFTS) (Q9B6D3) | Yarrowia lipolytica | |
| 40 | NA (6) | Subunit NU6M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 185 | 20765.1 | 1 | UniProt (Q9B6E9) Pfam (PF00499) | Yarrowia lipolytica | NADH dehydrogenase subunit 6, Subunit ND6 |
| 41 | OA (8) | Subunit NB8M of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 99 | 11219.0 | 1 | UniProt (A0A1H6PKH9) Pfam (PF05676) UniProt (by SIFTS) (B5FVG1) | Yarrowia lipolytica (Candida lipolytica) | |
| 42 | PA (9) | Subunit NIPM of NADH:Ubiquinone Oxidoreductase (Complex I) | polymer | 89 | 10035.7 | 1 | UniProt (A0A1D8NNZ0) Pfam (PF10200) UniProt (by SIFTS) (B5RSL7) | Yarrowia lipolytica (Candida lipolytica) | |
| 43 | EB, QA, RA, TA, YA... (K, A, B, I) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 44 | SA, WA (A, H) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 45 | UA (B) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) PubChem (710) PubChem (8965) PubChem (23585816) PubChem (643976) PubChem (51435500) PubChem (51435503) PubChem (5702760) PubChem (7048779) PubChem (7048781) PubChem (15559251) | |||
| 46 | VA (E) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 47 | AB, AC, CB, CC, DC... (J, 4, S, a, b...) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 11 | Chemie (3PE) | |||
| 48 | BB, DB, QB (J, j) | Lauryl Maltose Neopentyl Glycol | non-polymer | 1005.2 | 3 | Chemie (LMN) PubChem (49839603) PubChem (70678409) PubChem (75300949) PubChem (132285124) PubChem (126731017) PubChem (153502978) PubChem (172914192) | |||
| 49 | FB (M) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 50 | GB, HB (O, Q) | S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate | non-polymer | 568.7 | 2 | Chemie (ZMP) PubChem (24941266) PubChem (74369227) PubChem (119058172) | |||
| 51 | GC, HC, JB, KB, RB... (5, W, 1) | DIUNDECYL PHOSPHATIDYL CHOLINE | non-polymer | 622.8 | 6 | Chemie (PLC) PubChem (65263) PubChem (87507) PubChem (445355) | |||
| 52 | BC, FC, LB, MB, UB (4, 5, X, Z, 2) | CARDIOLIPIN | non-polymer | 1464.0 | 5 | Chemie (CDL) PubChem (17753886) PubChem (5287898) | |||
| 53 | SB (1) | Ubiquinone-9 | non-polymer | 795.2 | 1 | Chemie (UQ9) PubChem (99490) PubChem (97038294) PubChem (97038295) PubChem (5280473) PubChem (97038296) PubChem (125181414) PubChem (137350099) | |||
| 54 | EC, VB, XB, ZB (4, 2, 3) | Phosphatidylinositol | non-polymer | 887.1 | 4 | Chemie (T7X) PubChem (21226108) PubChem (42607491) PubChem (59423079) PubChem (71581204) PubChem (6441989) PubChem (174696) PubChem (72280035) PubChem (101025742) PubChem (101668931) PubChem (102207642) PubChem (10260108) PubChem (134744895) PubChem (123819699) PubChem (154815683) PubChem (162368813) PubChem (137350037) PubChem (162371041) PubChem (172878298) | |||
| 55 | WB (2) | (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE | non-polymer | 759.1 | 1 | Chemie (PSC) PubChem (122219) PubChem (446962) PubChem (46936343) PubChem (53962049) PubChem (5313189) PubChem (5313191) PubChem (5289212) PubChem (5313188) PubChem (5313190) PubChem (124586127) |
Sequence modifications
P: 1 - 124 (UniProt: A0A1D8N3C8)
g: 1 - 78 (UniProt: A0A1D8NJR0)
| PDB | External Database | Details |
|---|---|---|
| Ala 89 | Phe 89 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 71 | Gln 71 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 42 |
| Total formula weight | 978471.7 | |
| Non-Polymers* | Number of molecules | 44 |
| Total formula weight | 32270.4 | |
| All* | Total formula weight | 1010742.1 |
