6Y5D

Structure of human cGAS (K394E) bound to the nucleosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, M, Q (A, E, M, Q)	Histone H3.2	polymer	98	11456.3	4	UniProt (Q71DI3) Pfam (PF00125)	Homo sapiens (Human)	Histone H3/m,Histone H3/o
2	B, F, N, R (B, F, N, R)	Histone H4	polymer	103	11394.4	4	UniProt (P62805) Pfam (PF15511)	Homo sapiens (Human)
3	C, G, O, S (C, G, O, S)	Histone H2A type 2-A	polymer	130	14125.5	4	UniProt (Q6FI13) Pfam (PF00125) Pfam (PF16211)	Homo sapiens (Human)	Histone H2A.2,Histone H2A/o
4	D, H, P, T (D, H, P, T)	Histone H2B type 1-K	polymer	126	13921.2	4	UniProt (O60814) Pfam (PF00125)	Homo sapiens (Human)	H2B K,HIRA-interacting protein 1
5	I, U (I, U)	DNA (153-MER)	polymer	153	46998.9	2		Homo sapiens
6	J, V (J, V)	DNA (153-MER)	polymer	153	47457.2	2		Homo sapiens
7	K, L (K, L)	Cyclic GMP-AMP synthase	polymer	362	42404.8	2	UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266)	Homo sapiens (Human)	h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1
8	AA, DA, EA, FA, GA... (H, M, O, S, A...)	PENTANEDIAL	non-polymer		100.1	9	Chemie (PTD)
9	BA, CA (K, L)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A, E, M, Q: 39 - 136 (UniProt: Q71DI3)

PDB	External Database	Details
Ala 111	Cys 111	conflict

K, L: 161 - 522 (UniProt: Q8N884)

PDB	External Database	Details
Glu 394	Lys 394	conflict

Contents of the asymmetric unit

Polymers	Number of chains	22
	Total formula weight	477312.2
Non-Polymers*	Number of molecules	11
	Total formula weight	1031.9
All*	Total formula weight	478344.0

*Water molecules are not included.